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    Plekhh3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 [ Mus musculus (house mouse) ]

    Gene ID: 217198, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plekhh3provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 3provided by MGI
    Primary source
    MGI:MGI:2384950
    See related
    Ensembl:ENSMUSG00000035172 AllianceGenome:MGI:2384950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Orthologous to human PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 23.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 64.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101053505..101062205, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101162679..101171378, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2 Neighboring gene contactin associated protein-like 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27854

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family H member 3
    Names
    PH domain-containing family H member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346769.1 → NP_001333698.1  pleckstrin homology domain-containing family H member 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK164128, AL590969, BE332650
      Consensus CDS
      CCDS83899.1
      UniProtKB/Swiss-Prot
      Q8VCE9
      Related
      ENSMUSP00000127088.2, ENSMUST00000164474.8

    2. NM_146030.2 → NP_666142.1  pleckstrin homology domain-containing family H member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_666142.1

      Status: VALIDATED

      Source sequence(s)
      AL590969
      Consensus CDS
      CCDS25453.1
      UniProtKB/Swiss-Prot
      Q3U3Z6, Q8R1H2, Q8VCE9
      Related
      ENSMUSP00000046044.8, ENSMUST00000043397.14
      Conserved Domains (5) summary
      pfam00169
      Location:96 → 199
      PH; PH domain
      pfam00784
      Location:288 → 397
      MyTH4; MyTH4 domain
      cl00155
      Location:409 → 459
      UBQ; Ubiquitin-like proteins
      cl09511
      Location:514 → 553
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:84 → 208
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101053505..101062205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245873.2 → XP_030101733.1  pleckstrin homology domain-containing family H member 3 isoform X2

      Conserved Domains (4) summary
      pfam00784
      Location:62 → 173
      MyTH4; MyTH4 domain
      cl09511
      Location:287 → 325
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:433 → 520
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:177 → 273
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_030245871.2 → XP_030101731.1  pleckstrin homology domain-containing family H member 3 isoform X1

      Conserved Domains (4) summary
      pfam00784
      Location:62 → 173
      MyTH4; MyTH4 domain
      cl09511
      Location:290 → 328
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:436 → 523
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:177 → 276
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. XR_003949397.2 RNA Sequence

    2. XR_388417.5 RNA Sequence

      Related
      ENSMUST00000129895.8

    3. XR_003949401.2 RNA Sequence

    4. XR_003949399.2 RNA Sequence

    5. XR_003949400.2 RNA Sequence

    6. XR_003949398.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCE9.1 GenPept UniProtKB/Swiss-Prot:Q8VCE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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