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    Tns4 tensin 4 [ Mus musculus (house mouse) ]

    Gene ID: 217169, updated on 5-Mar-2024

    Summary

    Official Symbol
    Tns4provided by MGI
    Official Full Name
    tensin 4provided by MGI
    Primary source
    MGI:MGI:2144377
    See related
    Ensembl:ENSMUSG00000017607 AllianceGenome:MGI:2144377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cten; 9930017A07Rik
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in protein localization. Predicted to act upstream of or within apoptotic process. Predicted to be located in focal adhesion. Is expressed in dorsal root ganglion; left lung; orbito-sphenoid; right lung; and stomach. Orthologous to human TNS4 (tensin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 41.6), large intestine adult (RPKM 12.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    Location:
    11 D; 11 62.92 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98956504..98980132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99065678..99089306, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene topoisomerase (DNA) II alpha Neighboring gene STARR-positive B cell enhancer ABC_E17 Neighboring gene predicted gene, 23451 Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E377 Neighboring gene STARR-seq mESC enhancer starr_30701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:99009129-99009367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:99024171-99024372 Neighboring gene C-C motif chemokine receptor 7 Neighboring gene STARR-positive B cell enhancer ABC_E3997 Neighboring gene predicted gene, 32249

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172564.3NP_766152.2  tensin-4 precursor

      See identical proteins and their annotated locations for NP_766152.2

      Status: VALIDATED

      Source sequence(s)
      AK036834, AL591366, BY133848
      Consensus CDS
      CCDS25372.1
      UniProtKB/Swiss-Prot
      A2A552, Q3TCM8, Q7TNR5, Q8BZ33
      Related
      ENSMUSP00000017751.3, ENSMUST00000017751.3
      Conserved Domains (2) summary
      cd01213
      Location:561691
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cl15255
      Location:425538
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98956504..98980132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)