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    Scrn2 secernin 2 [ Mus musculus (house mouse) ]

    Gene ID: 217140, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Scrn2provided by MGI
    Official Full Name
    secernin 2provided by MGI
    Primary source
    MGI:MGI:1343092
    See related
    Ensembl:ENSMUSG00000020877 AllianceGenome:MGI:1343092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SES2; D11Moh48
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Is expressed in submandibular gland primordium; testis; and thymus primordium. Orthologous to human SCRN2 (secernin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 36.7), duodenum adult (RPKM 23.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 60.62 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96920717..96924786)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97029893..97033960)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916 Neighboring gene STARR-positive B cell enhancer ABC_E1429 Neighboring gene trans-acting transcription factor 6 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene predicted gene 11532 Neighboring gene leucine rich repeat containing 46 Neighboring gene predicted gene 11533 Neighboring gene STARR-positive B cell enhancer ABC_E909 Neighboring gene mitochondrial ribosomal protein L10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Houston BJ, et al. Dev Dyn, 2021 Jul. PMID 33442887, Free PMC Article
    2. Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Mohlke KL, et al. Genomics, 1998 Nov 15. PMID 9806826
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29406

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secernin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146027.2 → NP_666139.1  secernin-2

      See identical proteins and their annotated locations for NP_666139.1

      Status: VALIDATED

      Source sequence(s)
      AK075869, BF464943, CN691874
      Consensus CDS
      CCDS25310.1
      UniProtKB/Swiss-Prot
      Q8VCA8
      Related
      ENSMUSP00000021249.5, ENSMUST00000021249.11
      Conserved Domains (1) summary
      cl00467
      Location:11 → 401
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96920717..96924786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314480.3 → XP_017169969.1  secernin-2 isoform X1

      Conserved Domains (1) summary
      cl00467
      Location:29 → 419
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RNA

    1. XR_004936926.1 RNA Sequence

    2. XR_003949396.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCA8.1 GenPept UniProtKB/Swiss-Prot:Q8VCA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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