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    Evi2b ecotropic viral integration site 2b [ Mus musculus (house mouse) ]

    Gene ID: 216984, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Evi2bprovided by MGI
    Official Full Name
    ecotropic viral integration site 2bprovided by MGI
    Primary source
    MGI:MGI:1890682
    See related
    Ensembl:ENSMUSG00000093938 AllianceGenome:MGI:1890682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi2; Evi-2
    Summary
    Involved in several processes, including myeloid cell development; positive regulation of neutrophil differentiation; and regulation of stem cell division. Is expressed in several structures, including Harderian gland; alimentary system; hemolymphoid system; integumental system; and reproductive system. Orthologous to human EVI2B (ecotropic viral integration site 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 20.2), thymus adult (RPKM 15.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79404211..79414588, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79513385..79523762, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene STARR-seq mESC enhancer starr_30120 Neighboring gene expressed sequence AU040972 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2 Neighboring gene ecotropic viral integration site 2a Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II) Neighboring gene predicted gene, 23293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evi-2, a common integration site involved in murine myeloid leukemogenesis. Buchberg AM, et al. Mol Cell Biol, 1990 Sep. PMID 2167436, Free PMC Article
    2. EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors. Zjablovskaja P, et al. Cell Death Differ, 2017 Apr. PMID 28186500, Free PMC Article
    3. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. Venturin M, et al. Ann Hum Genet, 2005 Sep. PMID 16138909
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Evi2

    Readthrough gene: Evi2, Included gene: Evi2a

    Homology

    Clone Names

    • MGC28913

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in myeloid cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein EVI2B
    Names
    EVI-2B
    ecotropic viral integration site 2B protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077496.1 → NP_001070964.1  protein EVI2B precursor

      See identical proteins and their annotated locations for NP_001070964.1

      Status: VALIDATED

      Source sequence(s)
      AK039968, AL591174, BY196178
      Consensus CDS
      CCDS25121.1
      UniProtKB/Swiss-Prot
      Q3U1A3, Q8VD58
      Related
      ENSMUSP00000136153.2, ENSMUST00000179322.2
      Conserved Domains (1) summary
      PRK13335
      Location:32 → 169
      PRK13335; superantigen-like protein; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79404211..79414588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD58.1 GenPept UniProtKB/Swiss-Prot:Q8VD58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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