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    Taok1 TAO kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 216965, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Taok1provided by MGI
    Official Full Name
    TAO kinase 1provided by MGI
    Primary source
    MGI:MGI:1914490
    See related
    Ensembl:ENSMUSG00000017291 AllianceGenome:MGI:1914490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psk2; Markk; Map3k16; 2810468K05Rik; D130018F14Rik
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; protein C-terminus binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of JNK cascade; and regulation of cytoskeleton organization. Predicted to act upstream of or within DNA repair and apoptotic process. Predicted to be located in microtubule cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; lung; nervous system; and retina. Orthologous to human TAOK1 (TAO kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.8), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taok1 in Genome Data Viewer
    Location:
    11 B5; 11 46.64 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77419988..77516185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77529162..77625359, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene predicted gene 10392 Neighboring gene abhydrolase domain containing 15 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8973 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase. Beeman N, et al. Sci Signal, 2023 Jan 3. PMID 36595571, Free PMC Article
    2. TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development. van Woerden GM, et al. Hum Mutat, 2021 Apr. PMID 33565190, Free PMC Article
    3. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Draviam VM, et al. Nat Cell Biol, 2007 May. PMID 17417629
    4. Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. Gunther CV, et al. Genes Dev, 1990 Apr. PMID 2163347
    5. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. Hutchison M, et al. J Biol Chem, 1998 Oct 30. PMID 9786855

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
      Title: Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
    2. Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.
      Title: Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.
    3. Isolation and functional characterization of the rat Taok1 ortholog, and comparison to human TAOK1.
      Title: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.
    4. Functional analysis of the human Tao1 ortholog.
      Title: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29021, mKIAA1361

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase TAO1
    Names
    serine/threonine protein kinase TAO1 homolog
    thousand and one amino acid protein 1
    NP_001351062.1
    NP_001351063.1
    NP_659074.2
    XP_006533022.1
    XP_006533023.1
    XP_011247232.1
    XP_030101697.1
    XP_036012472.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364133.1 → NP_001351062.1  serine/threonine-protein kinase TAO1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442 → 877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2 → 318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    2. NM_001364134.1 → NP_001351063.1  serine/threonine-protein kinase TAO1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442 → 877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2 → 318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    3. NM_144825.3 → NP_659074.2  serine/threonine-protein kinase TAO1

      See identical proteins and their annotated locations for NP_659074.2

      Status: VALIDATED

      Source sequence(s)
      AK013386, AK143530, AK173156, BC034906, BE691513, CF164486, CN717576, CN717636, CN718413, CN721819, CN724017, CN724388
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Related
      ENSMUSP00000055470.8, ENSMUST00000058496.8
      Conserved Domains (2) summary
      COG0419
      Location:442 → 877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2 → 318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77419988..77516185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245837.2 → XP_030101697.1  serine/threonine-protein kinase TAO1 isoform X1

      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Related
      ENSMUSP00000017435.5, ENSMUST00000017435.11
      Conserved Domains (2) summary
      COG0419
      Location:442 → 877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2 → 318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    2. XM_011248930.4 → XP_011247232.1  serine/threonine-protein kinase TAO1 isoform X1

      See identical proteins and their annotated locations for XP_011247232.1

      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442 → 877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2 → 318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    3. XM_006532960.4 → XP_006533023.1  serine/threonine-protein kinase TAO1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:194 → 625
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:11 → 70
      PKc_like; Protein Kinases, catalytic domain
      cl27706
      Location:656 → 713
      Prion; Prion/Doppel alpha-helical domain

    4. XM_006532959.5 → XP_006533022.1  serine/threonine-protein kinase TAO1 isoform X1

      See identical proteins and their annotated locations for XP_006533022.1

      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442 → 877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2 → 318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    5. XM_036156579.1 → XP_036012472.1  serine/threonine-protein kinase TAO1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:194 → 625
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:11 → 70
      PKc_like; Protein Kinases, catalytic domain
      cl27706
      Location:656 → 713
      Prion; Prion/Doppel alpha-helical domain

    RNA

    1. XR_004936918.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F2E8.1 GenPept UniProtKB/Swiss-Prot:Q5F2E8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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