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    Slc16a11 solute carrier family 16 (monocarboxylic acid transporters), member 11 [ Mus musculus (house mouse) ]

    Gene ID: 216867, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Slc16a11provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 11provided by MGI
    Primary source
    MGI:MGI:2663709
    See related
    Ensembl:ENSMUSG00000040938 AllianceGenome:MGI:2663709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCT 11; MNCb-2717
    Summary
    Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in lipid metabolic process and monocarboxylic acid transport. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC16A11 (solute carrier family 16 member 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 54.4), cerebellum adult (RPKM 29.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc16a11 in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70104717..70107239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70213695..70216414)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12311 Neighboring gene macrophage galactose N-acetyl-galactosamine specific lectin 2 Neighboring gene STARR-seq mESC enhancer starr_29870 Neighboring gene C-type lectin domain family 10, member A Neighboring gene STARR-seq mESC enhancer starr_29871 Neighboring gene STARR-seq mESC enhancer starr_29872 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 13 Neighboring gene B cell CLL/lymphoma 6, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice. Zhang T, et al. Exp Clin Endocrinol Diabetes, 2021 Feb. PMID 31185508
    2. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, et al. Cell Rep, 2019 Jan 22. PMID 30673611
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice.
      Title: Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice.
    2. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
      Title: Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 11
    Names
    novel RNA polymerase Rpb1 C-terminal repeat domain containing protein
    solute carrier family 16 member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416062.1 → NP_001402991.1  monocarboxylate transporter 11

      Status: VALIDATED

      Source sequence(s)
      AL669869
      UniProtKB/Swiss-Prot
      A2BDD4, Q5NC32, Q5NC33
      Related
      ENSMUSP00000091597.4, ENSMUST00000094055.10

    2. NM_001416063.1 → NP_001402992.1  monocarboxylate transporter 11

      Status: VALIDATED

      Source sequence(s)
      AL669869
      UniProtKB/Swiss-Prot
      A2BDD4, Q5NC32, Q5NC33

    3. NM_153081.4 → NP_694721.2  monocarboxylate transporter 11

      See identical proteins and their annotated locations for NP_694721.2

      Status: VALIDATED

      Source sequence(s)
      AL669869
      UniProtKB/Swiss-Prot
      A2BDD4, Q5NC32, Q5NC33
      UniProtKB/TrEMBL
      B7ZCB5
      Related
      ENSMUSP00000128419.2, ENSMUST00000171032.8
      Conserved Domains (1) summary
      cl28910
      Location:14 → 403
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70104717..70107239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001114970.1: Suppressed sequence

      Description
      NM_001114970.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001114971.1: Suppressed sequence

      Description
      NM_001114971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NC32.1 GenPept UniProtKB/Swiss-Prot:Q5NC32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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