Tec tec protein tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tecprovided by MGI
Official Full Name: tec protein tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:98662
See related: Ensembl:ENSMUSG00000029217 AllianceGenome:MGI:98662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine autophosphorylation; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to act upstream of or within immune system process and phosphorylation. Located in cell-cell junction. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and spleen. Orthologous to human TEC (tec protein tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 4.6), spleen adult (RPKM 4.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.2; 5 38.44 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (72913061..73025997, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (72755718..72868654, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation.
Title: The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation.
Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic.
Title: ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.
Results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 macrophages cells via NF-kappaB pathway.
Title: Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway.
these data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase.
Title: Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.
Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.
Title: Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.
identify dectin-1 as the pathogen recognition receptor being required for Syk-dependent Tec activation.
Title: The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.
Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Title: The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
Tec kinase can act as a prosurvival factor and is regulated by IGF-I in human neutrophils through PI(3)K activation.
Title: Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils.
TEC promotes hepatocyte proliferation and regeneration and is involved in Hepatocyte Growth Factor-induced Erk signaling pathway.
Title: TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF.
our data indicated a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44(high)CD62L(-) effector/memory Th17 populations.
Title: The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RW11 (e-PCR)
- UniSTS:241559

Tec (e-PCR), detects polymorphism
- UniSTS:166296

D5Mit134 (e-PCR), detects polymorphism
- UniSTS:130260

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of platelet activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase Tec

Names: cytoplasmic tyrosine kinase, Dscr28C related; protein tyrosine kinase TecI; protein tyrosine kinase TecIIA; protein tyrosine kinase TecIIB; protein tyrosine kinase TecIII; protein tyrosine kinase TecIV

NP_001106931.1

EC 2.7.10.2

NP_001106932.1

EC 2.7.10.2

NP_001106935.1

EC 2.7.10.2

NP_038717.2

EC 2.7.10.2

XP_006503908.1

EC 2.7.10.2

XP_006503909.1

EC 2.7.10.2

XP_006503910.1

EC 2.7.10.2

XP_006503911.1

EC 2.7.10.2

XP_011239020.1

EC 2.7.10.2

XP_011239021.1

EC 2.7.10.2

XP_036020885.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113460.2 → NP_001106931.1 tyrosine-protein kinase Tec isoform a

See identical proteins and their annotated locations for NP_001106931.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC099698, AK139329, AK168460, CJ047828

Consensus CDS

CCDS51516.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

UniProtKB/TrEMBL

Q3U436

Related

ENSMUSP00000071836.7, ENSMUST00000071944.13

Conserved Domains (4) summary

cd10396
Location:239 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 236

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:364 → 623

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
NM_001113461.2 → NP_001106932.1 tyrosine-protein kinase Tec isoform b

See identical proteins and their annotated locations for NP_001106932.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter than isoform a.

Source sequence(s)

AC099698, AK168452, AK168460, CJ047828

Consensus CDS

CCDS51515.1

UniProtKB/TrEMBL

Q3TH41, Q8CFK4

Related

ENSMUSP00000073509.7, ENSMUST00000073843.13

Conserved Domains (6) summary

cd10396
Location:220 → 324

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:342 → 601

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

pfam00169
Location:5 → 111

PH; PH domain

pfam07714
Location:347 → 596

Pkinase_Tyr; Protein tyrosine kinase

cl17036
Location:182 → 223

SH3; Src Homology 3 domain superfamily
NM_001113464.2 → NP_001106935.1 tyrosine-protein kinase Tec isoform a

See identical proteins and their annotated locations for NP_001106935.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC099698, AK139329, CJ047828

Consensus CDS

CCDS51516.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

UniProtKB/TrEMBL

Q3U436

Related

ENSMUSP00000109224.2, ENSMUST00000113594.8

Conserved Domains (4) summary

cd10396
Location:239 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 236

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:364 → 623

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
NM_013689.5 → NP_038717.2 tyrosine-protein kinase Tec isoform c

See identical proteins and their annotated locations for NP_038717.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate in-frame exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c, which is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC099698, AK133418, AK139329

UniProtKB/TrEMBL

Q3TH41

Conserved Domains (5) summary

cd10396
Location:139 → 243

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd05114
Location:261 → 520

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

pfam07714
Location:266 → 515

Pkinase_Tyr; Protein tyrosine kinase

cl17036
Location:101 → 142

SH3; Src Homology 3 domain superfamily

cl17171
Location:11 → 67

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

72913061..73025997 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503846.5 → XP_006503909.1 tyrosine-protein kinase Tec isoform X1

See identical proteins and their annotated locations for XP_006503909.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

UniProtKB/TrEMBL

Q3U436

Conserved Domains (4) summary

cd10396
Location:239 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 236

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:364 → 623

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
XM_011240719.4 → XP_011239021.1 tyrosine-protein kinase Tec isoform X1

See identical proteins and their annotated locations for XP_011239021.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

UniProtKB/TrEMBL

Q3U436

Conserved Domains (4) summary

cd10396
Location:239 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 236

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:364 → 623

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
XM_006503845.5 → XP_006503908.1 tyrosine-protein kinase Tec isoform X1

See identical proteins and their annotated locations for XP_006503908.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

UniProtKB/TrEMBL

Q3U436

Conserved Domains (4) summary

cd10396
Location:239 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 236

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:364 → 623

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
XM_011240718.3 → XP_011239020.1 tyrosine-protein kinase Tec isoform X1

See identical proteins and their annotated locations for XP_011239020.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

UniProtKB/TrEMBL

Q3U436

Conserved Domains (4) summary

cd10396
Location:239 → 346

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:182 → 236

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd01238
Location:7 → 148

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cd05114
Location:364 → 623

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
XM_006503848.5 → XP_006503911.1 tyrosine-protein kinase Tec isoform X3

See identical proteins and their annotated locations for XP_006503911.1

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

Conserved Domains (4) summary

cd10396
Location:158 → 265

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:101 → 155

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd05114
Location:283 → 542

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

cl17171
Location:11 → 67

PH-like; Pleckstrin homology-like domain
XM_006503847.2 → XP_006503910.1 tyrosine-protein kinase Tec isoform X2

UniProtKB/Swiss-Prot

P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3

Conserved Domains (4) summary

cd10396
Location:206 → 313

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:149 → 203

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd05114
Location:331 → 590

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

cl17171
Location:9 → 115

PH-like; Pleckstrin homology-like domain
XM_036164992.1 → XP_036020885.1 tyrosine-protein kinase Tec isoform X4

UniProtKB/TrEMBL

I6L9F0

Conserved Domains (3) summary

cd10396
Location:54 → 161

SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)

cd11905
Location:1 → 51

SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)

cd05114
Location:179 → 438

PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase