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    Dhrs7b dehydrogenase/reductase 7B [ Mus musculus (house mouse) ]

    Gene ID: 216820, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dhrs7bprovided by MGI
    Official Full Name
    dehydrogenase/reductase 7Bprovided by MGI
    Primary source
    MGI:MGI:2384931
    See related
    Ensembl:ENSMUSG00000042569 AllianceGenome:MGI:2384931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PexRAP
    Summary
    Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in ether lipid biosynthetic process and neutrophil differentiation. Acts upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane; nucleus; and peroxisome. Part of transcription regulator complex. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 20.2), mammary gland adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B2; 11 37.87 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60721457..60749249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60830631..60858423)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene serine hydroxymethyltransferase 1 (soluble) Neighboring gene STARR-positive B cell enhancer ABC_E6992 Neighboring gene phosphoserine aminotransferase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8411 Neighboring gene transmembrane protein 11 Neighboring gene STARR-positive B cell enhancer ABC_E10679 Neighboring gene STARR-seq mESC enhancer starr_29661 Neighboring gene predicted gene, 26534

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Lodhi IJ, et al. Cell Metab, 2012 Aug 8. PMID 22863804, Free PMC Article
    2. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Lodhi IJ, et al. Cell Metab, 2015 Jan 6. PMID 25565205, Free PMC Article
    3. PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Lodhi IJ, et al. Cell Rep, 2017 Sep 19. PMID 28930673, Free PMC Article
    4. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    5. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6908

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables acylglycerone-phosphate reductase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ether lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 7B
    Names
    dehydrogenase/reductase (SDR family) member 7B
    short-chain dehydrogenase/reductase family 32C member 1
    NP_001165583.1
    NP_663403.1
    XP_006532932.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172112.1 → NP_001165583.1  dehydrogenase/reductase SDR family member 7B isoform 1

      See identical proteins and their annotated locations for NP_001165583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK139084, AL596215
      UniProtKB/TrEMBL
      Z4YKT6
      Related
      ENSMUSP00000104358.2, ENSMUST00000108718.2
      Conserved Domains (2) summary
      cd05332
      Location:41 → 300
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:45 → 310
      PRK06181; short chain dehydrogenase; Provisional

    2. NM_145428.2 → NP_663403.1  dehydrogenase/reductase SDR family member 7B isoform 2

      See identical proteins and their annotated locations for NP_663403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AK052209, AK139084, AL596215
      Consensus CDS
      CCDS24800.1
      UniProtKB/Swiss-Prot
      Q3UNS3, Q5NCT5, Q99J47
      UniProtKB/TrEMBL
      I7DM66, Z4YKT6
      Related
      ENSMUSP00000044924.8, ENSMUST00000042281.14
      Conserved Domains (2) summary
      cd05332
      Location:50 → 309
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:52 → 319
      PRK06181; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60721457..60749249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532869.5 → XP_006532932.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      Z4YKT6
      Conserved Domains (1) summary
      cd05332
      Location:48 → 307
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J47.1 GenPept UniProtKB/Swiss-Prot:Q99J47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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