Tead2 TEA domain family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tead2provided by MGI
Official Full Name: TEA domain family member 2provided by MGI
Primary source: MGI:MGI:104904
See related: Ensembl:ENSMUSG00000030796 AllianceGenome:MGI:104904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ETF; Etdf; TEF4; TEF-4; ETEF-1; TEAD-2
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell death. Acts upstream of or within several processes, including cellular response to retinoic acid; mesenchyme development; and tube morphogenesis. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb bud. Orthologous to human TEAD2 (TEA domain transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 109.8), limb E14.5 (RPKM 100.2) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.19 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44865216..44882892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45215792..45233468)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
Title: Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.
Title: Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.
Identification of novel Taz isoforms and functional comparison in pluripotency maintenance of mouse embryonic stem cells.
Title: Identification of novel Taz isoforms and functional comparison in pluripotency maintenance of mouse embryonic stem cells.
Tead transcription factors differentially regulate cortical development.
Title: Tead transcription factors differentially regulate cortical development.
Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mouse mesoderm.
Title: Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.
Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc RNA expression, and cells with increased Myc expression also became super-competitors.
Title: Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc.
Tead2 transcription factors are crucial regulators of the cellular distribution of Yap and Taz, and together they control the expression of genes critical for EMT and metastasis.
Title: Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP/TEAD pathway
Title: Serum Inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells.
These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein.
Title: Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
YAP, TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF.
Title: Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125491 (e-PCR)
- UniSTS:162310

D50563 (e-PCR)
- UniSTS:163416

PMC110775P1 (e-PCR)
- UniSTS:270199

D7Mit364 (e-PCR), detects polymorphism
- UniSTS:131263

Tead2 (e-PCR), detects polymorphism
- UniSTS:144597

Tead2 (e-PCR), detects polymorphism
- UniSTS:548084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesenchyme development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of TEAD-YAP complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcriptional enhancer factor TEF-4

Names: embryonic TEA domain-containing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285498.2 → NP_001272427.1 transcriptional enhancer factor TEF-4 isoform a

See identical proteins and their annotated locations for NP_001272427.1

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variants 2, 4, and 5, encodes the longer isoform (a).

Source sequence(s)

AC150897

Consensus CDS

CCDS21236.1

UniProtKB/Swiss-Prot

P48301, Q62297

UniProtKB/TrEMBL

Q3UMJ5, Q3UPV9

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:226 → 442

YBD; YAP binding domain
NM_001285500.2 → NP_001272429.1 transcriptional enhancer factor TEF-4 isoform b

See identical proteins and their annotated locations for NP_001272429.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC150897

Consensus CDS

CCDS71957.1

UniProtKB/TrEMBL

Q3UMJ5, Q80UL2

Related

ENSMUSP00000103430.2, ENSMUST00000097216.5

Conserved Domains (1) summary

cl02603
Location:43 → 72

TEA; TEA/ATTS domain family
NM_001379272.1 → NP_001366201.1 transcriptional enhancer factor TEF-4 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AC150897

UniProtKB/Swiss-Prot

P48301, Q62297

UniProtKB/TrEMBL

Q3UMJ5, Q3UPV9

Related

ENSMUSP00000103431.2, ENSMUST00000107801.10

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:226 → 442

YBD; YAP binding domain
NM_001379273.1 → NP_001366202.1 transcriptional enhancer factor TEF-4 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variants 1, 2, and 4, encodes the longer isoform (a).

Source sequence(s)

AC150897

UniProtKB/Swiss-Prot

P48301, Q62297

UniProtKB/TrEMBL

Q3UMJ5, Q3UPV9

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:226 → 442

YBD; YAP binding domain
NM_011565.3 → NP_035695.1 transcriptional enhancer factor TEF-4 isoform a

See identical proteins and their annotated locations for NP_035695.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (a).

Source sequence(s)

AC150897

Consensus CDS

CCDS21236.1

UniProtKB/Swiss-Prot

P48301, Q62297

UniProtKB/TrEMBL

Q3UMJ5, Q3UPV9

Related

ENSMUSP00000033060.7, ENSMUST00000033060.14

Conserved Domains (2) summary

smart00426
Location:40 → 107

TEA; TEA domain

pfam17725
Location:226 → 442

YBD; YAP binding domain