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    Mfap3 microfibrillar-associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 216760, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mfap3provided by MGI
    Official Full Name
    microfibrillar-associated protein 3provided by MGI
    Primary source
    MGI:MGI:1924068
    See related
    Ensembl:ENSMUSG00000020522 AllianceGenome:MGI:1924068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610509F16Rik; 2700079M14Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in genitourinary system and heart ventricle. Orthologous to human MFAP3 (microfibril associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 10.8), CNS E14 (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 35.27 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57409478..57424643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57518652..57533817)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 53706 Neighboring gene family with sequence similarity 114, member A2 Neighboring gene STARR-positive B cell enhancer ABC_E1825 Neighboring gene STARR-seq mESC enhancer starr_29572 Neighboring gene predicted gene, 51895 Neighboring gene RIKEN cDNA 4933424L21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:57458544-57458653 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
    2. Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Georgas KM, et al. Dev Dyn, 2011 Jun. PMID 21491542, Free PMC Article
    3. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microfibril-associated glycoprotein 3
    Names
    novel immunoglobulin domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145426.2 → NP_663401.2  microfibril-associated glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_663401.2

      Status: VALIDATED

      Source sequence(s)
      AK042988, AL672236, BY203406, CF174749
      Consensus CDS
      CCDS24718.1
      UniProtKB/Swiss-Prot
      Q8BHK5, Q922T2
      UniProtKB/TrEMBL
      A0A0R4J1C7
      Related
      ENSMUSP00000020830.8, ENSMUST00000020830.14
      Conserved Domains (1) summary
      smart00408
      Location:60 → 123
      IGc2; Immunoglobulin C-2 Type

    2. NM_180599.1 → NP_850930.1  microfibril-associated glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_850930.1

      Status: VALIDATED

      Source sequence(s)
      AL672236, CF174749
      Consensus CDS
      CCDS24718.1
      UniProtKB/Swiss-Prot
      Q8BHK5, Q922T2
      UniProtKB/TrEMBL
      A0A0R4J1C7
      Related
      ENSMUSP00000104477.2, ENSMUST00000108849.8
      Conserved Domains (1) summary
      smart00408
      Location:60 → 123
      IGc2; Immunoglobulin C-2 Type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      57409478..57424643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532851.1 → XP_006532914.1  microfibril-associated glycoprotein 3 isoform X2

    2. XM_006532850.4 → XP_006532913.1  microfibril-associated glycoprotein 3 isoform X1

      See identical proteins and their annotated locations for XP_006532913.1

      UniProtKB/Swiss-Prot
      Q8BHK5, Q922T2
      UniProtKB/TrEMBL
      A0A0R4J1C7
      Conserved Domains (1) summary
      smart00408
      Location:60 → 123
      IGc2; Immunoglobulin C-2 Type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922T2.1 GenPept UniProtKB/Swiss-Prot:Q922T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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