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    Nmur2 neuromedin U receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 216749, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nmur2provided by MGI
    Official Full Name
    neuromedin U receptor 2provided by MGI
    Primary source
    MGI:MGI:2441765
    See related
    Ensembl:ENSMUSG00000037393 AllianceGenome:MGI:2441765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nmu2r
    Summary
    Enables neuropeptide receptor activity. Acts upstream of or within several processes, including grooming behavior; neuropeptide signaling pathway; and reduction of food intake in response to dietary excess. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 1.4), subcutaneous fat pad adult (RPKM 1.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 33.39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55915816..55931813, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (56024990..56040987, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12236 Neighboring gene STARR-seq mESC enhancer starr_29547 Neighboring gene glycine receptor, alpha 1 subunit Neighboring gene STARR-seq mESC enhancer starr_29550 Neighboring gene STARR-seq mESC enhancer starr_29551 Neighboring gene STARR-seq mESC enhancer starr_29552 Neighboring gene STARR-seq mESC enhancer starr_29553 Neighboring gene predicted gene, 50502 Neighboring gene STARR-seq mESC enhancer starr_29554 Neighboring gene predicted gene 12239 Neighboring gene STARR-seq mESC enhancer starr_29558 Neighboring gene predicted gene, 46260 Neighboring gene predicted gene 12240 Neighboring gene predicted gene, 24253

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice. Gilbert AK, et al. Eur J Pain, 2013 Sep. PMID 23349076
    2. Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice. Egecioglu E, et al. Am J Physiol Endocrinol Metab, 2009 Sep. PMID 19584200
    3. Neuromedin-U is regulated by the circadian clock in the SCN of the mouse. Graham ES, et al. Eur J Neurosci, 2005 Feb. PMID 15733101
    4. Cloning and characterization of murine neuromedin U receptors. Funes S, et al. Peptides, 2002 Sep. PMID 12217421
    5. Appetite-modifying actions of pro-neuromedin U-derived peptides. Bechtold DA, et al. Am J Physiol Endocrinol Metab, 2009 Aug. PMID 19531638, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
      Title: Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
    2. Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
      Title: Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
    3. Neuromedin U (NMU) regulates osteoblast differentiation and activity.
      Title: Neuromedin U (NMU) regulates osteoblast differentiation and activity.
    4. The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation
      Title: Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice.
    5. Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
      Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
    6. Long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
      Title: Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
    7. The circadian rhythm of neuromedin U expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor in the paraventricular nucleus.
      Title: Neuromedin-U is regulated by the circadian clock in the SCN of the mouse.
    8. molecular basis of the NMU2R regulation of food intake and body weight in mice
      Title: Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.
    9. the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1
      Title: Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
    10. Plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding.
      Title: Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuromedin U binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuromedin U receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reduction of food intake in response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuromedin-U receptor 2
    Names
    NMU-R2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153079.4 → NP_694719.2  neuromedin-U receptor 2

      See identical proteins and their annotated locations for NP_694719.2

      Status: PROVISIONAL

      Source sequence(s)
      AL671969
      Consensus CDS
      CCDS24716.1
      UniProtKB/Swiss-Prot
      Q8BZ39, Q91Z76
      UniProtKB/TrEMBL
      B2RPU9
      Related
      ENSMUSP00000044718.3, ENSMUST00000037682.3
      Conserved Domains (2) summary
      pfam00001
      Location:54 → 319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48 → 333
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      55915816..55931813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ39.1 GenPept UniProtKB/Swiss-Prot:Q8BZ39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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