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    Acsl6 acyl-CoA synthetase long-chain family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 216739, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Acsl6provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 6provided by MGI
    Primary source
    MGI:MGI:894291
    See related
    Ensembl:ENSMUSG00000020333 AllianceGenome:MGI:894291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LACS; Facl6; Lacsl; mKIAA0837; A330035H04Rik
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Acts upstream of or within neuroblast proliferation. Located in mitochondrion. Is expressed in heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 31.2), cortex adult (RPKM 27.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acsl6 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54194580..54255582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54303805..54364756)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene interleukin 3 Neighboring gene STARR-seq mESC enhancer starr_29507 Neighboring gene predicted gene, 51861 Neighboring gene predicted gene 12224 Neighboring gene meiotic kinetochore factor Neighboring gene mucolipin 2 pseudogene Neighboring gene oxidative stress responsive 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging. Fernandez RF, et al. JCI Insight, 2021 Jun 8. PMID 34100386, Free PMC Article
    2. Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes. Jung YH, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Jul. PMID 32126286
    3. Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse. Hale BJ, et al. J Biol Chem, 2019 Sep 27. PMID 31399511, Free PMC Article
    4. Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain. Fernandez RF, et al. Proc Natl Acad Sci U S A, 2018 Dec 4. PMID 30401738, Free PMC Article
    5. Alternative promotion of the mouse acyl-CoA synthetase 6 (mAcsl6) gene mediates the expression of multiple transcripts with 5'-end heterogeneity: genetic organization of mAcsl6 variants. Lee EJ, et al. Biochem Biophys Res Commun, 2005 Feb 4. PMID 15629433

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice.
      Title: Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice.
    2. Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
      Title: Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
    3. Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging.
      Title: Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging.
    4. Acyl-CoA synthetase 6 regulates DHA and DPA composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice
      Title: Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.
    5. Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes.
      Title: Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes.
    6. ACSL6 is essential for germ cell DHA enrichment and is required for normal spermatogenesis and male fertility.
      Title: Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse.
    7. Acsl6 knockout mice demonstrate motor impairments, altered glutamate metabolism, and increased astrogliosis and microglia activation.
      Title: Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain.
    8. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
      Title: ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
    9. Long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation.
      Title: A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation.
    10. Acsl6 promoter 1 (mAcsl6_pr1) region has a negative regulatory function
      Title: Alternative promotion of the mouse acyl-CoA synthetase 6 (mAcsl6) gene mediates the expression of multiple transcripts with 5'-end heterogeneity: genetic organization of mAcsl6 variants.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of long-chain fatty acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 6
    Names
    LACS 6
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 6
    long-chain acyl-CoA synthetase 6
    NP_001028769.1
    NP_001028770.1
    NP_001028771.1
    NP_659072.3
    XP_006532906.1
    XP_006532907.1
    XP_006532908.1
    XP_030101661.1
    XP_030101662.1
    XP_036012431.1
    XP_036012432.1
    XP_036012433.1
    XP_036012434.1
    XP_036012435.1
    XP_036012436.1
    XP_036012437.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033597.1 → NP_001028769.1  long-chain-fatty-acid--CoA ligase 6 isoform 2

      See identical proteins and their annotated locations for NP_001028769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is the same length as but includes an alternative in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region.
      Source sequence(s)
      AL596127, AL603822, BC022959
      Consensus CDS
      CCDS24694.1
      UniProtKB/TrEMBL
      Q5ICG6, Q8R1X1
      Related
      ENSMUSP00000104532.4, ENSMUST00000108904.10
      Conserved Domains (2) summary
      PLN02736
      Location:104 → 718
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:141 → 718
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. NM_001033598.1 → NP_001028770.1  long-chain-fatty-acid--CoA ligase 6 isoform 3

      See identical proteins and their annotated locations for NP_001028770.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK147283
      Consensus CDS
      CCDS24696.1
      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Related
      ENSMUSP00000090795.6, ENSMUST00000093106.12
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. NM_001033599.1 → NP_001028771.1  long-chain-fatty-acid--CoA ligase 6 isoform 4

      See identical proteins and their annotated locations for NP_001028771.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region and uses a downstream start codon, and also includes an alternative in-frame exon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus and also differs in an internal region, compared to isoform 1.
      Source sequence(s)
      AL596127, AY786362, BB634066
      Consensus CDS
      CCDS24697.1
      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Related
      ENSMUSP00000098773.3, ENSMUST00000101213.9
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    4. NM_144823.4 → NP_659072.3  long-chain-fatty-acid--CoA ligase 6 isoform 1

      See identical proteins and their annotated locations for NP_659072.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AK147421
      Consensus CDS
      CCDS24695.1
      UniProtKB/TrEMBL
      Q5F2D0, Q5ICG6
      Related
      ENSMUSP00000104533.4, ENSMUST00000108905.10
      Conserved Domains (2) summary
      PLN02736
      Location:104 → 718
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:141 → 718
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54194580..54255582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245801.2 → XP_030101661.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. XM_036156542.1 → XP_036012435.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      UniProtKB/TrEMBL
      A8IP90
      Conserved Domains (1) summary
      cd05927
      Location:116 → 667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. XM_030245802.2 → XP_030101662.1  long-chain-fatty-acid--CoA ligase 6 isoform X6

      UniProtKB/TrEMBL
      Q5ICG6
      Conserved Domains (1) summary
      cd05927
      Location:141 → 744
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    4. XM_036156540.1 → XP_036012433.1  long-chain-fatty-acid--CoA ligase 6 isoform X3

      UniProtKB/TrEMBL
      Q5ICG6
      Conserved Domains (1) summary
      cd05927
      Location:141 → 692
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    5. XM_006532843.2 → XP_006532906.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

      See identical proteins and their annotated locations for XP_006532906.1

      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Related
      ENSMUSP00000072040.5, ENSMUST00000072178.11
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    6. XM_036156541.1 → XP_036012434.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      UniProtKB/TrEMBL
      A8IP90
      Conserved Domains (1) summary
      cd05927
      Location:116 → 667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    7. XM_036156538.1 → XP_036012431.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    8. XM_006532844.1 → XP_006532907.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

      See identical proteins and their annotated locations for XP_006532907.1

      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    9. XM_036156543.1 → XP_036012436.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      UniProtKB/TrEMBL
      A8IP90
      Conserved Domains (1) summary
      cd05927
      Location:116 → 667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    10. XM_036156539.1 → XP_036012432.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Related
      ENSMUSP00000098771.3, ENSMUST00000101211.9
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    11. XM_006532845.3 → XP_006532908.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

      See identical proteins and their annotated locations for XP_006532908.1

      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Conserved Domains (1) summary
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    12. XM_036156544.1 → XP_036012437.1  long-chain-fatty-acid--CoA ligase 6 isoform X5

      UniProtKB/TrEMBL
      Q80TQ7
      Conserved Domains (1) summary
      cl17068
      Location:1 → 369
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_004936915.1 RNA Sequence

    2. XR_003949381.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WC3.1 GenPept UniProtKB/Swiss-Prot:Q91WC3

    Gene LinkOut

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