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    Papolg poly(A) polymerase gamma [ Mus musculus (house mouse) ]

    Gene ID: 216578, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Papolgprovided by MGI
    Official Full Name
    poly(A) polymerase gammaprovided by MGI
    Primary source
    MGI:MGI:2442119
    See related
    Ensembl:ENSMUSG00000020273 AllianceGenome:MGI:2442119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630006B20Rik
    Summary
    Predicted to enable metal ion binding activity and polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Orthologous to human PAPOLG (poly(A) polymerase gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 4.0), CNS E11.5 (RPKM 4.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A3.2; 11 14.37 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23810145..23845292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23860145..23895293, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticuloendotheliosis oncogene Neighboring gene STARR-seq mESC enhancer starr_28924 Neighboring gene predicted gene, 39612 Neighboring gene STARR-seq mESC enhancer starr_28925 Neighboring gene STARR-positive B cell enhancer mm9_chr11:23795118-23795419 Neighboring gene STARR-seq mESC enhancer starr_28926 Neighboring gene predicted gene 12061 Neighboring gene STARR-seq mESC enhancer starr_28927 Neighboring gene STARR-seq mESC enhancer starr_28928 Neighboring gene RIKEN cDNA A830031A19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:23949249-23949549 Neighboring gene STARR-positive B cell enhancer mm9_chr11:23977830-23978131 Neighboring gene predicted gene, 57804 Neighboring gene STARR-seq mESC enhancer starr_28930 Neighboring gene STARR-seq mESC enhancer starr_28931 Neighboring gene BCL11 transcription factor A Neighboring gene STARR-positive B cell enhancer ABC_E9360 Neighboring gene RIKEN cDNA 4930538E20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) polymerase gamma
    Names
    PAP-gamma
    SRP 3'-adenylating protein
    SRP RNA 3'-adenylating enzyme
    SRP RNA-adenylating enzyme
    polynucleotide adenylyltransferase gamma
    signal recognition particle RNA-adenylating enzyme
    NP_766143.2
    XP_006514716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172555.2 → NP_766143.2  poly(A) polymerase gamma

      See identical proteins and their annotated locations for NP_766143.2

      Status: VALIDATED

      Source sequence(s)
      AK035810, BC023030, CJ075859, DQ103505
      Consensus CDS
      CCDS24481.1
      UniProtKB/Swiss-Prot
      Q6PCL9, Q8BZC9
      Related
      ENSMUSP00000020513.4, ENSMUST00000020513.10
      Conserved Domains (3) summary
      PTZ00418
      Location:3 → 569
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:365 → 504
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:20 → 363
      PAP_central; Poly(A) polymerase central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23810145..23845292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514653.5 → XP_006514716.1  poly(A) polymerase gamma isoform X1

      Conserved Domains (3) summary
      PTZ00449
      Location:481 → 715
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam04926
      Location:357 → 495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:12 → 354
      PAP_central; Poly(A) polymerase central domain

    RNA

    1. XR_380964.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCL9.1 GenPept UniProtKB/Swiss-Prot:Q6PCL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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