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    Cep68 centrosomal protein 68 [ Mus musculus (house mouse) ]

    Gene ID: 216543, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cep68provided by MGI
    Official Full Name
    centrosomal protein 68provided by MGI
    Primary source
    MGI:MGI:2667663
    See related
    Ensembl:ENSMUSG00000044066 AllianceGenome:MGI:2667663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0582; 6030463E10Rik
    Summary
    Predicted to enable protein domain specific binding activity and protein kinase binding activity. Predicted to be involved in centriole-centriole cohesion and protein localization to organelle. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; telencephalon ventricular layer; and vibrissa. Orthologous to human CEP68 (centrosomal protein 68). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 13.8), heart adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A3.1; 11 12.92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (20177037..20199424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (20227037..20249424, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28788 Neighboring gene predicted gene, 26253 Neighboring gene RAB1A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_28789 Neighboring gene STARR-seq mESC enhancer starr_28791 Neighboring gene STARR-positive B cell enhancer ABC_E6955 Neighboring gene predicted gene, 39604 Neighboring gene STARR-seq mESC enhancer starr_28794 Neighboring gene ribosomal proteimn L12-ps2 Neighboring gene solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E6956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. Fuchs S, et al. BMC Genet, 2002 Aug 13. PMID 12174196, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6990

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 68 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172260.3 → NP_758464.2  centrosomal protein of 68 kDa

      See identical proteins and their annotated locations for NP_758464.2

      Status: PROVISIONAL

      Source sequence(s)
      AK140820
      Consensus CDS
      CCDS24456.1
      UniProtKB/Swiss-Prot
      Q3US49, Q5SW85, Q8C0D9, Q8R2V0
      UniProtKB/TrEMBL
      Q3ULV4
      Related
      ENSMUSP00000054943.8, ENSMUST00000050611.14
      Conserved Domains (1) summary
      cl02488
      Location:605 → 700
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      20177037..20199424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0D9.2 GenPept UniProtKB/Swiss-Prot:Q8C0D9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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