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    Rdh16f2 RDH16 family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 216454, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rdh16f2provided by MGI
    Official Full Name
    RDH16 family member 2provided by MGI
    Primary source
    MGI:MGI:3583955
    See related
    Ensembl:ENSMUSG00000074639 AllianceGenome:MGI:3583955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRAD-L
    Summary
    Predicted to enable androstan-3-alpha,17-beta-diol dehydrogenase activity and androsterone dehydrogenase activity. Predicted to be involved in positive regulation of retinoic acid biosynthetic process; retinoid metabolic process; and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of organelle membrane. Is expressed in urinary system. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 164.0) and liver adult (RPKM 115.7) See more
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    Genomic context

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    Location:
    10 D3; 10 76.39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127702345..127713188)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127866476..127877319)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 18, pseudogene Neighboring gene STARR-seq mESC enhancer starr_28240 Neighboring gene retinol dehydrogenase 19 Neighboring gene predicted gene, 31091 Neighboring gene STARR-seq mESC enhancer starr_28247 Neighboring gene retinol dehydrogenase 7 Neighboring gene STARR-seq mESC enhancer starr_28249 Neighboring gene 4short chain dehydrogenase/reductase family 9C, member 7 Neighboring gene STARR-seq mESC enhancer starr_28250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107618

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145424.2 → NP_663399.2  cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like precursor

      See identical proteins and their annotated locations for NP_663399.2

      Status: VALIDATED

      Source sequence(s)
      AI099357, AK144071, AY053572
      Consensus CDS
      CCDS24254.1
      UniProtKB/TrEMBL
      Q8K3M1, Q8VCY3
      Related
      ENSMUSP00000089691.4, ENSMUST00000092058.4
      Conserved Domains (2) summary
      cd09805
      Location:30 → 307
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:30 → 219
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127702345..127713188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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