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    Rab3ip RAB3A interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 216363, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab3ipprovided by MGI
    Official Full Name
    RAB3A interacting proteinprovided by MGI
    Primary source
    MGI:MGI:105933
    See related
    Ensembl:ENSMUSG00000064181 AllianceGenome:MGI:105933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rabin3; Gtpat12; B230311A06
    Summary
    Predicted to enable GTPase binding activity; guanyl-nucleotide exchange factor activity; and identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; negative regulation of filopodium assembly; and protein targeting to membrane. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and proximal dendrite. Predicted to be active in Golgi to plasma membrane transport vesicle. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human RAB3IP (RAB3A interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 46.3), testis adult (RPKM 22.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab3ip in Genome Data Viewer
    Location:
    10 D2; 10 64.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116741685..116786361, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (116905780..116950456, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930579P08 gene Neighboring gene STARR-positive B cell enhancer mm9_chr10:116183775-116184076 Neighboring gene myelin regulatory factor-like Neighboring gene STARR-seq mESC enhancer starr_27965 Neighboring gene STARR-seq mESC enhancer starr_27966 Neighboring gene STARR-seq mESC enhancer starr_27967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:116367664-116367817 Neighboring gene predicted gene, 51782 Neighboring gene RIKEN cDNA 4933412E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10645 Neighboring gene RIKEN cDNA D630029K05 gene Neighboring gene predicted gene, 40768

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new strategy of gene trapping in ES cells using 3'RACE. Yoshida M, et al. Transgenic Res, 1995 Jul. PMID 7655516
    2. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
    3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90794

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi to plasma membrane transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab-3A-interacting protein
    Names
    SSX2-interacting protein
    gene trap PAT 12
    rab3A-interacting protein
    rabin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003950.3 → NP_001003950.1  rab-3A-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001003950.1

      Status: VALIDATED

      Source sequence(s)
      AK045783, BC080289, BM938945, BY059863
      Consensus CDS
      CCDS24186.1
      UniProtKB/Swiss-Prot
      Q68EF0
      Related
      ENSMUSP00000020375.7, ENSMUST00000020375.7
      Conserved Domains (1) summary
      pfam08614
      Location:160 → 209
      ATG16; Autophagy protein 16 (ATG16)

    2. NM_001359645.1 → NP_001346574.1  rab-3A-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA980340, AK045783, AK152122, BM938945, BY059863
      Consensus CDS
      CCDS88090.1
      UniProtKB/TrEMBL
      A0A1W2P7K6
      Related
      ENSMUSP00000151708.2, ENSMUST00000219109.2
      Conserved Domains (2) summary
      COG4372
      Location:104 → 240
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam06428
      Location:173 → 241
      Sec2p; GDP/GTP exchange factor Sec2p

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      116741685..116786361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513546.4 → XP_006513609.1  rab-3A-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006513609.1

      UniProtKB/TrEMBL
      A0A1W2P7K6
      Conserved Domains (2) summary
      COG4372
      Location:104 → 240
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam06428
      Location:173 → 241
      Sec2p; GDP/GTP exchange factor Sec2p

    2. XM_030245041.1 → XP_030100901.1  rab-3A-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q68EF0
      Conserved Domains (1) summary
      pfam08614
      Location:160 → 209
      ATG16; Autophagy protein 16 (ATG16)

    3. XM_006513544.2 → XP_006513607.1  rab-3A-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006513607.1

      UniProtKB/TrEMBL
      A0A1W2P7K6
      Conserved Domains (2) summary
      COG4372
      Location:104 → 240
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam06428
      Location:173 → 241
      Sec2p; GDP/GTP exchange factor Sec2p

    4. XM_006513547.4 → XP_006513610.1  rab-3A-interacting protein isoform X3

      Conserved Domains (1) summary
      pfam06428
      Location:4 → 72
      Sec2p; GDP/GTP exchange factor Sec2p

    5. XM_017313908.2 → XP_017169397.1  rab-3A-interacting protein isoform X4

    6. XM_006513548.5 → XP_006513611.1  rab-3A-interacting protein isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68EF0.1 GenPept UniProtKB/Swiss-Prot:Q68EF0

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