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    Cdc34 cell division cycle 34 [ Mus musculus (house mouse) ]

    Gene ID: 216150, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cdc34provided by MGI
    Official Full Name
    cell division cycle 34provided by MGI
    Primary source
    MGI:MGI:102657
    See related
    Ensembl:ENSMUSG00000020307 AllianceGenome:MGI:102657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBE2R1; E2-CDC34
    Summary
    Enables ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including cellular protein metabolic process; cellular response to interferon-beta; and negative regulation of cAMP-mediated signaling. Predicted to be located in cytosol and nuclear speck. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 167.9), placenta adult (RPKM 79.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79518029..79524232)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79682193..79688398)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E8346 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E3896 Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene predicted gene, 25794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reprogrammable recognition codes in bicoid homeodomain-DNA interaction. Dave V, et al. Mol Cell Biol, 2000 Oct. PMID 11003663, Free PMC Article
    2. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Gray S, et al. Cell Rep, 2020 Jul 7. PMID 32640224, Free PMC Article
    3. Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Campbell PK, et al. Genetics, 2002 Sep. PMID 12242242, Free PMC Article
    4. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. Plon SE, et al. Proc Natl Acad Sci U S A, 1993 Nov 15. PMID 8248134, Free PMC Article
    5. Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities. Choi YS, et al. J Biol Chem, 2015 Jan 23. PMID 25471371, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 R1
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme R1
    E2 ubiquitin-conjugating enzyme R1
    cell division cycle 34 homolog
    ubiquitin-conjugating enzyme Cdc34
    ubiquitin-conjugating enzyme E2-32 kDa complementing
    ubiquitin-conjugating enzyme E2-CDC34
    ubiquitin-protein ligase R1
    NP_001346746.1
    NP_001346747.1
    NP_808281.1
    XP_017169376.1
    XP_017169377.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359817.1 → NP_001346746.1  ubiquitin-conjugating enzyme E2 R1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151828, BE988402, BY083281, BY114161, CA320111
      Consensus CDS
      CCDS88049.1
      UniProtKB/TrEMBL
      A0A1W2P7U1
      Related
      ENSMUSP00000151763.2, ENSMUST00000219791.2
      Conserved Domains (1) summary
      cd00195
      Location:11 → 125
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001359818.1 → NP_001346747.1  ubiquitin-conjugating enzyme E2 R1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151828, BE988402, BY114161, CA320111, CX210748
      UniProtKB/TrEMBL
      A0A1W2P7U9
      Related
      ENSMUSP00000152000.2, ENSMUST00000218964.2
      Conserved Domains (1) summary
      cd00195
      Location:11 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_177613.2 → NP_808281.1  ubiquitin-conjugating enzyme E2 R1 isoform 1

      See identical proteins and their annotated locations for NP_808281.1

      Status: VALIDATED

      Source sequence(s)
      BC039160
      Consensus CDS
      CCDS23983.1
      UniProtKB/Swiss-Prot
      Q505K8, Q8CFI2
      UniProtKB/TrEMBL
      A0A087WP01
      Related
      ENSMUSP00000020550.6, ENSMUST00000020550.13
      Conserved Domains (1) summary
      cd00195
      Location:11 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79518029..79524232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313888.3 → XP_017169377.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/Swiss-Prot
      Q505K8, Q8CFI2
      UniProtKB/TrEMBL
      A0A087WP01
      Conserved Domains (1) summary
      cd00195
      Location:11 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. XM_017313887.2 → XP_017169376.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/Swiss-Prot
      Q505K8, Q8CFI2
      UniProtKB/TrEMBL
      A0A087WP01
      Conserved Domains (1) summary
      cd00195
      Location:11 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFI2.1 GenPept UniProtKB/Swiss-Prot:Q8CFI2

    Gene LinkOut

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