Shc2 SHC (Src homology 2 domain containing) transforming protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shc2provided by MGI
Official Full Name: SHC (Src homology 2 domain containing) transforming protein 2provided by MGI
Primary source: MGI:MGI:106180
See related: Ensembl:ENSMUSG00000020312 AllianceGenome:MGI:106180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCK; Sli; ShcB; 6720466E06
Summary: Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including epidermis; liver; nervous system; sensory organ; and skeleton. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 14.0), whole brain E14.5 (RPKM 11.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79453768..79473752, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79617934..79637918, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.
Title: Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Shc2 (e-PCR), detects polymorphism
- UniSTS:532500

NoName (e-PCR)
- UniSTS:236397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SHC-transforming protein 2

Names: SH2 domain protein C2; SHC-transforming protein B; protein Sck; protein Sli; src homology 2 domain-containing-transforming protein C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024539.1 → NP_001019710.1 SHC-transforming protein 2

See identical proteins and their annotated locations for NP_001019710.1

Status: VALIDATED

Source sequence(s)

AK032878, BB646065, BC059866

Consensus CDS

CCDS48620.1

UniProtKB/Swiss-Prot

Q8BMC3

Related

ENSMUSP00000020564.7, ENSMUST00000020564.7

Conserved Domains (2) summary

cd09925
Location:470 → 573

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:116 → 285

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain