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    Rfpl4b ret finger protein-like 4B [ Mus musculus (house mouse) ]

    Gene ID: 215919, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rfpl4bprovided by MGI
    Official Full Name
    ret finger protein-like 4Bprovided by MGI
    Primary source
    MGI:MGI:2684908
    See related
    Ensembl:ENSMUSG00000094311 AllianceGenome:MGI:2684908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm62; Gm3037; 100040915
    Summary
    Predicted to enable several functions, including promoter-specific chromatin binding activity; transcription corepressor activity; and ubiquitin-protein transferase activity. Predicted to be involved in innate immune response; protein sumoylation; and regulation of transcription, DNA-templated. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in chromatin and nucleoplasm. Orthologous to human RFPL4B (ret finger protein like 4B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B1; 10 19.98 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (38696537..38697775, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (38820541..38821779, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40624 Neighboring gene STARR-seq mESC enhancer starr_26369 Neighboring gene STARR-seq mESC enhancer starr_26371 Neighboring gene STARR-seq mESC enhancer starr_26372 Neighboring gene predicted gene, 22911 Neighboring gene STARR-seq mESC enhancer starr_26375 Neighboring gene STARR-seq mESC enhancer starr_26376 Neighboring gene STARR-seq mESC enhancer starr_26377 Neighboring gene STARR-seq mESC enhancer starr_26378 Neighboring gene predicted gene, 17779 Neighboring gene laminin, alpha 4 Neighboring gene STARR-seq mESC enhancer starr_26379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ret finger protein-like 4B
    Names
    ret finger protein-like 4 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177783.1 → NP_001171254.1  ret finger protein-like 4B

      See identical proteins and their annotated locations for NP_001171254.1

      Status: VALIDATED

      Source sequence(s)
      AC153539
      Consensus CDS
      CCDS56699.1
      UniProtKB/TrEMBL
      J3QPR6
      Related
      ENSMUSP00000137446.2, ENSMUST00000179279.2
      Conserved Domains (2) summary
      cd00162
      Location:30 → 75
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02614
      Location:132 → 237
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      38696537..38697775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_018788.1: Suppressed sequence

      Description
      NG_018788.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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