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    Miga1 mitoguardin 1 [ Mus musculus (house mouse) ]

    Gene ID: 215708, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Miga1provided by MGI
    Official Full Name
    mitoguardin 1provided by MGI
    Primary source
    MGI:MGI:1924567
    See related
    Ensembl:ENSMUSG00000054942 AllianceGenome:MGI:1924567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mita1; Fam73a; A930038D06; C030011O14Rik
    Summary
    Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Predicted to be located in mitochondrion. Predicted to be integral component of plasma membrane. Is expressed in brain; metanephros; spinal cord; and testis. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 11.0), cortex adult (RPKM 9.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 H3; 3 77.1 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151979096..152046073, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152273459..152340436, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:151922476-151922776 Neighboring gene nexilin Neighboring gene predicted gene, 31999 Neighboring gene VISTA enhancer mm72 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ domain containing 3 Neighboring gene predicted gene, 57837

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Qiu Z, et al. Nucleic Acids Res, 2013 Jun. PMID 23630316, Free PMC Article
    2. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability. Gao Z, et al. Nat Commun, 2017 Nov 27. PMID 29180626, Free PMC Article
    3. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Liu XM, et al. Oncotarget, 2016 Jan 12. PMID 26716412, Free PMC Article
    4. Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation. Liu XM, et al. Endocrinology, 2017 Nov 1. PMID 28938432
    5. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Zhang Y, et al. Mol Cell, 2016 Jan 7. PMID 26711011

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ovarian phenotypes of these mice suggested that MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins.
      Title: Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
    2. Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile.
      Title: Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.
    3. Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
      Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitoguardin 1
    Names
    family with sequence similarity 73, member A
    protein FAM73A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162375.1 → NP_001155847.1  mitoguardin 1 isoform 2

      See identical proteins and their annotated locations for NP_001155847.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC123075, AK045347, AK085017
      Consensus CDS
      CCDS51096.1
      UniProtKB/Swiss-Prot
      Q4QQM5
      Related
      ENSMUSP00000068261.7, ENSMUST00000068243.11
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 507
      DUF2217; Uncharacterized conserved protein (DUF2217)

    2. NM_174868.4 → NP_777357.2  mitoguardin 1 isoform 1

      See identical proteins and their annotated locations for NP_777357.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123075, AK085017, BC098205
      Consensus CDS
      CCDS17916.1
      UniProtKB/Swiss-Prot
      Q4QQM5, Q8BR91, Q8C3S6, Q8C8P4
      UniProtKB/TrEMBL
      B2RRB9
      Related
      ENSMUSP00000072836.7, ENSMUST00000073089.13
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 571
      DUF2217; Uncharacterized conserved protein (DUF2217)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      151979096..152046073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163015.1 → XP_036018908.1  mitoguardin 1 isoform X3

      Conserved Domains (1) summary
      pfam10265
      Location:2 → 306
      Miga; Mitoguardin

    2. XM_011240070.4 → XP_011238372.1  mitoguardin 1 isoform X1

      Related
      ENSMUSP00000143238.2, ENSMUST00000199334.5
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 489
      Miga; Mitoguardin

    3. XM_036163016.1 → XP_036018909.1  mitoguardin 1 isoform X4

      Conserved Domains (1) summary
      pfam10265
      Location:27 → 301
      Miga; Mitoguardin

    4. XM_036163014.1 → XP_036018907.1  mitoguardin 1 isoform X2

      Conserved Domains (1) summary
      pfam10265
      Location:27 → 339
      Miga; Mitoguardin

    RNA

    1. XR_001783676.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQM5.1 GenPept UniProtKB/Swiss-Prot:Q4QQM5

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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