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    Arrdc1 arrestin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 215705, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Arrdc1provided by MGI
    Official Full Name
    arrestin domain containing 1provided by MGI
    Primary source
    MGI:MGI:2446136
    See related
    Ensembl:ENSMUSG00000026972 AllianceGenome:MGI:2446136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including extracellular vesicle biogenesis; negative regulation of Notch signaling pathway; and protein ubiquitination. Predicted to be located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; nasal cavity epithelium; and respiratory system. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 119.7), colon adult (RPKM 105.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A3; 2 16.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24815364..24825347, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24925352..24935335, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene STARR-positive B cell enhancer ABC_E5898 Neighboring gene zinc finger, MYND domain containing 19 Neighboring gene diphthamine biosynethesis 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of the divalent metal ion transporter via membrane budding. Mackenzie K, et al. Cell Discov, 2016. PMID 27462458, Free PMC Article
    2. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    3. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28029

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular vesicle biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arrestin domain-containing protein 1
    Names
    alpha-arrestin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162485.1 → NP_001155957.1  arrestin domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001155957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL732525
      Consensus CDS
      CCDS50521.1
      UniProtKB/Swiss-Prot
      A2AIS7, A2AIS8, Q3TDT6, Q8VEG7, Q99KN1
      Related
      ENSMUSP00000028349.8, ENSMUST00000028349.14
      Conserved Domains (2) summary
      pfam02752
      Location:162 → 283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_178408.3 → NP_848495.2  arrestin domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AL732525
      Consensus CDS
      CCDS15741.1
      UniProtKB/Swiss-Prot
      Q99KN1
      Related
      ENSMUSP00000099999.4, ENSMUST00000102935.10
      Conserved Domains (2) summary
      pfam02752
      Location:162 → 282
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. NR_027876.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL732525
      Related
      ENSMUST00000155953.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24815364..24825347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497841.1 → XP_006497904.1  arrestin domain-containing protein 1 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:244 → 384
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:117 → 239
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:18 → 94
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. XM_006497839.3 → XP_006497902.1  arrestin domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:288 → 428
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162 → 283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. XM_006497838.3 → XP_006497901.1  arrestin domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:289 → 429
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162 → 284
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    4. XM_006497840.5 → XP_006497903.1  arrestin domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:252 → 392
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:125 → 247
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:14 → 102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    5. XM_030249390.2 → XP_030105250.1  arrestin domain-containing protein 1 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:252 → 386
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:125 → 247
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:14 → 102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    6. XM_006497842.3 → XP_006497905.1  arrestin domain-containing protein 1 isoform X6

      Conserved Domains (2) summary
      smart01017
      Location:34 → 107
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      PHA03247
      Location:112 → 252
      PHA03247; large tegument protein UL36; Provisional

    7. XM_036160423.1 → XP_036016316.1  arrestin domain-containing protein 1 isoform X7

      Conserved Domains (2) summary
      smart01017
      Location:34 → 107
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      PHA03247
      Location:112 → 246
      PHA03247; large tegument protein UL36; Provisional

    8. XM_030249391.1 → XP_030105251.1  arrestin domain-containing protein 1 isoform X6

      Conserved Domains (2) summary
      smart01017
      Location:34 → 107
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      PHA03247
      Location:112 → 252
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_003952025.2 RNA Sequence

    2. XR_003952030.2 RNA Sequence

    3. XR_004939481.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KN1.2 GenPept UniProtKB/Swiss-Prot:Q99KN1

    Gene LinkOut

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