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    Senp6 SUMO/sentrin specific peptidase 6 [ Mus musculus (house mouse) ]

    Gene ID: 215351, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Senp6provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 6provided by MGI
    Primary source
    MGI:MGI:1922075
    See related
    Ensembl:ENSMUSG00000034252 AllianceGenome:MGI:1922075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Susp1; mKIAA0797; 2810017C20Rik; E130319N12Rik
    Summary
    Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein desumoylation; regulation of kinetochore assembly; and regulation of spindle assembly. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo. Orthologous to human SENP6 (SUMO specific peptidase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.8), CNS E14 (RPKM 11.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 E1; 9 43.88 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (79973862..80052064)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (80066575..80144782)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene filamin A interacting protein 1 Neighboring gene predicted gene, 53505 Neighboring gene STARR-seq mESC enhancer starr_24749 Neighboring gene STARR-seq mESC enhancer starr_24751 Neighboring gene STARR-seq mESC enhancer starr_24752 Neighboring gene STARR-seq mESC enhancer starr_24753 Neighboring gene STARR-seq mESC enhancer starr_24754 Neighboring gene STARR-positive B cell enhancer ABC_E715 Neighboring gene 5'-nucleotidase domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8303 Neighboring gene predicted gene, 46146 Neighboring gene STARR-positive B cell enhancer ABC_E3848 Neighboring gene myosin VI Neighboring gene predicted gene 27227 Neighboring gene STARR-seq mESC enhancer starr_24757 Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene methyltransferase like 9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Li J, et al. Nat Commun, 2018 Jan 10. PMID 29321472, Free PMC Article
    2. Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis. Xia Q, et al. Theranostics, 2021. PMID 34158860, Free PMC Article
    3. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6. Liu X, et al. PLoS Pathog, 2013. PMID 23825957, Free PMC Article
    4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
      Title: Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
    2. postnatal loss of the desumoylase SUMO1/sentrin-specific peptidase 6 (SENP6) causes premature aging. OCP-specific SENP6 knockout mice exhibit smaller skeletons, with elevated apoptosis and cell senescence in OCPs and chondrocytes. SENP6 interacts with, desumoylates, and stabilizes TRIM28, suppressing p53 activity.
      Title: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.
    3. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.
      Title: Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38009

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification by small protein removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sentrin-specific protease 6
    Names
    SUMO-1-specific protease 1
    SUMO/sentrin specific protease 6
    sentrin/SUMO-specific protease SENP6
    NP_001298039.1
    NP_666115.2
    XP_006511077.1
    XP_006511078.1
    XP_006511079.1
    XP_006511080.1
    XP_030100089.1
    XP_030100090.1
    XP_036010718.1
    XP_036010719.1
    XP_036010720.1
    XP_036010721.1
    XP_036010722.1
    XP_036010723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311110.1 → NP_001298039.1  sentrin-specific protease 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK053904, AK083377, BC052718
      Consensus CDS
      CCDS81040.1
      UniProtKB/TrEMBL
      B7ZWN9, F6Z9A1
      Related
      ENSMUSP00000126777.3, ENSMUST00000165607.9
      Conserved Domains (1) summary
      cl23802
      Location:707 → 819
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_146003.2 → NP_666115.2  sentrin-specific protease 6 isoform 2

      See identical proteins and their annotated locations for NP_666115.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK028461, AK048485, AK053904, AK083377
      Consensus CDS
      CCDS40705.1
      UniProtKB/Swiss-Prot
      E9QN09, Q6P7W0, Q6ZQ43, Q8BK94, Q8BUL4
      UniProtKB/TrEMBL
      B7ZWN9
      Related
      ENSMUSP00000047220.9, ENSMUST00000037484.15
      Conserved Domains (1) summary
      cl23802
      Location:700 → 812
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      79973862..80052064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511016.5 → XP_006511079.1  sentrin-specific protease 6 isoform X4

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:513 → 624
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:822 → 898
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. XM_036154825.1 → XP_036010718.1  sentrin-specific protease 6 isoform X3

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:564 → 675
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:873 → 949
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    3. XM_006511017.5 → XP_006511080.1  sentrin-specific protease 6 isoform X5

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:506 → 617
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:815 → 891
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    4. XM_006511014.3 → XP_006511077.1  sentrin-specific protease 6 isoform X1

      See identical proteins and their annotated locations for XP_006511077.1

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:583 → 694
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:892 → 968
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    5. XM_036154827.1 → XP_036010720.1  sentrin-specific protease 6 isoform X3

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:564 → 675
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:873 → 949
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    6. XM_030244229.2 → XP_030100089.1  sentrin-specific protease 6 isoform X2

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:576 → 687
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:885 → 961
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    7. XM_036154826.1 → XP_036010719.1  sentrin-specific protease 6 isoform X3

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:564 → 675
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:873 → 949
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    8. XM_006511015.5 → XP_006511078.1  sentrin-specific protease 6 isoform X1

      See identical proteins and their annotated locations for XP_006511078.1

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:583 → 694
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:892 → 968
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    9. XM_036154828.1 → XP_036010721.1  sentrin-specific protease 6 isoform X3

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:564 → 675
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:873 → 949
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    10. XM_030244230.2 → XP_030100090.1  sentrin-specific protease 6 isoform X2

      UniProtKB/TrEMBL
      B7ZWN9
      Conserved Domains (2) summary
      COG5160
      Location:576 → 687
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:885 → 961
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    11. XM_036154830.1 → XP_036010723.1  sentrin-specific protease 6 isoform X6

      Conserved Domains (2) summary
      COG5160
      Location:399 → 510
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:708 → 784
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    12. XM_036154829.1 → XP_036010722.1  sentrin-specific protease 6 isoform X3

      UniProtKB/TrEMBL
      B7ZWN9
      Related
      ENSMUSP00000128918.2, ENSMUST00000164859.8
      Conserved Domains (2) summary
      COG5160
      Location:564 → 675
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      cl23802
      Location:873 → 949
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176927.2: Suppressed sequence

      Description
      NM_176927.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7W0.3 GenPept UniProtKB/Swiss-Prot:Q6P7W0

    Gene LinkOut

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