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    Wipf1 WAS/WASL interacting protein family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 215280, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wipf1provided by MGI
    Official Full Name
    WAS/WASL interacting protein family, member 1provided by MGI
    Primary source
    MGI:MGI:2178801
    See related
    Ensembl:ENSMUSG00000075284 AllianceGenome:MGI:2178801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WIP; Waspip; D2Ertd120e
    Summary
    Predicted to enable SH3 domain binding activity. Acts upstream of or within actin filament-based movement and response to other organism. Located in actin filament. Orthologous to human WIPF1 (WAS/WASL interacting protein family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 10.8), thymus adult (RPKM 7.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C3; 2 43.68 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73259954..73359831, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73429610..73529487, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene secernin 3 Neighboring gene STARR-seq mESC enhancer starr_04837 Neighboring gene G protein-coupled receptor 155 Neighboring gene predicted gene 13709 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73224453-73224754 Neighboring gene predicted gene 13707 Neighboring gene STARR-positive B cell enhancer ABC_E2623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73288549-73288732 Neighboring gene STARR-positive B cell enhancer ABC_E4467 Neighboring gene STARR-positive B cell enhancer ABC_E1245 Neighboring gene STARR-positive B cell enhancer ABC_E5934 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73324434-73324587 Neighboring gene STARR-positive B cell enhancer ABC_E2038 Neighboring gene predicted gene, 54162 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73378889-73379190 Neighboring gene STARR-positive B cell enhancer ABC_E10115 Neighboring gene predicted gene, 30940 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit Neighboring gene cholinergic receptor nicotinic alpha 1 subunit, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities. Franco-Villanueva A, et al. Brain Behav, 2015 Nov. PMID 26664784, Free PMC Article
    2. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Massaad MJ, et al. Mol Cell Biol, 2014 Dec 1. PMID 25246631, Free PMC Article
    3. The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP). Wong AR, et al. Cell Microbiol, 2012 Jul. PMID 22372637, Free PMC Article
    4. WIP null mice display a progressive immunological disorder that resembles Wiskott-Aldrich syndrome. Curcio C, et al. J Pathol, 2007 Jan. PMID 17086554
    5. A role for WASP Interacting Protein, WIP, in fibroblast adhesion, spreading and migration. Lanzardo S, et al. Int J Biochem Cell Biol, 2007. PMID 17008118

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy.
      Title: CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy.
    2. WIP binding to actin, independent of its binding to WASp, is critical for actin cytoskeleton plasticity in B cells.
      Title: The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses.
    3. These experiments identify WIP as a member of a signaling cascade comprised of Abl family kinases, mTORC1 and S6K, which regulates neuron development and specifically, neuritic branching and complexity.
      Title: Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities.
    4. WIP is a link between membrane lipid composition and actin cytoskeleton at dendritic spines.
      Title: WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes.
    5. WIPf1 deficiency results in defective B cell function. By regulating the cortical actin cytoskeleton, WIPf1 influences the function of CD19 as a general hub for PI3K signaling.
      Title: Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.
    6. WIP binding to actin, independently of its binding to Wiskott-Aldrich syndrome protein, is critical for the integrity of the actin cytoskeleton in T cells and for their migration into tissues.
      Title: Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.
    7. Results show that WIP is a novel regulator of focal adhesion assembly and cell adhesion.
      Title: Binding of the WASP/N-WASP-interacting protein WIP to actin regulates focal adhesion assembly and adhesion.
    8. Data indicate the involvement of WIP (WASP Interacting Protein) in the control of migratory persistence in both mesenchymal (fibroblast) and amoeboid (B lymphocytes) motility.
      Title: WIP regulates persistence of cell migration and ruffle formation in both mesenchymal and amoeboid modes of motility.
    9. Using mouse embryonic fibroblasts lacking Nck, WIP, or N-WASP, this study investigated whether an interaction of Nck with both WIP and N-WASP is required for their recruitment to vaccinia during Arp2/3-dependent actin assembly.
      Title: WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.
    10. These data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly.
      Title: Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WAS/WASL-interacting protein family member 1
    Names
    WASP interacting protein
    Wiskott-Aldrich syndrome protein interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289722.1 → NP_001276651.1  WAS/WASL-interacting protein family member 1

      See identical proteins and their annotated locations for NP_001276651.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AJ437262, AK031046, AK054142, AL928813, AV338046, BB740185, BU756544
      Consensus CDS
      CCDS16131.1
      UniProtKB/Swiss-Prot
      Q3U0U8, Q8K1I7
      Related
      ENSMUSP00000099740.2, ENSMUST00000102679.8
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    2. NM_001289723.1 → NP_001276652.1  WAS/WASL-interacting protein family member 1

      See identical proteins and their annotated locations for NP_001276652.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AJ437262, AK031046, AK054142, AV338046, BB740185, BU756544, BY200699
      Consensus CDS
      CCDS16131.1
      UniProtKB/Swiss-Prot
      Q3U0U8, Q8K1I7
      Related
      ENSMUSP00000099741.2, ENSMUST00000102680.8
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    3. NM_153138.4 → NP_694778.1  WAS/WASL-interacting protein family member 1

      See identical proteins and their annotated locations for NP_694778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AJ437262, AK031046, AK054142, AV338046, BB740185, BU756544, BY252790, BY285630
      Consensus CDS
      CCDS16131.1
      UniProtKB/Swiss-Prot
      Q3U0U8, Q8K1I7
      Related
      ENSMUSP00000092268.5, ENSMUST00000094681.11
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73259954..73359831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160349.1 → XP_036016242.1  WAS/WASL-interacting protein family member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0U8, Q8K1I7
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    2. XM_006499124.5 → XP_006499187.1  WAS/WASL-interacting protein family member 1 isoform X1

      See identical proteins and their annotated locations for XP_006499187.1

      UniProtKB/Swiss-Prot
      Q3U0U8, Q8K1I7
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1

    3. XM_006499127.2 → XP_006499190.1  WAS/WASL-interacting protein family member 1 isoform X1

      See identical proteins and their annotated locations for XP_006499190.1

      UniProtKB/Swiss-Prot
      Q3U0U8, Q8K1I7
      Conserved Domains (1) summary
      cd22076
      Location:29 → 60
      WH2_WAS_WASL-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein family member 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1I7.1 GenPept UniProtKB/Swiss-Prot:Q8K1I7

    Gene LinkOut

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