Il36g interleukin 36G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il36gprovided by MGI
Official Full Name: interleukin 36Gprovided by MGI
Primary source: MGI:MGI:2449929
See related: Ensembl:ENSMUSG00000044103 AllianceGenome:MGI:2449929
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If36g; Il1f9; IL-36gamma
Summary: Enables cytokine activity. Acts upstream of or within negative regulation of myoblast differentiation; negative regulation of myoblast fusion; and positive regulation of interleukin-6 production. Located in extracellular space. Orthologous to human IL36G (interleukin 36 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.24 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24076488..24083579)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24186476..24193567)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-36gamma Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.
Title: IL-36γ Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.
Role of interleukin-36gamma induced by ultraviolet radiation in chronic actinic dermatitis.
Title: Role of interleukin-36γ induced by ultraviolet radiation in chronic actinic dermatitis.
Interleukin-36gamma is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice.
Title: Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice.
IL-36gamma is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores.
Title: IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores.
Non-immune and immune functions of interleukin-36gamma suppress epithelial repair at the ocular surface.
Title: Non-immune and immune functions of interleukin-36γ suppress epithelial repair at the ocular surface.
Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.
Title: Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.
Interleukin-36gamma aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice.
Title: Interleukin-36γ aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice.
Thrombospondin-1 Restricts Interleukin-36gamma-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.
Title: Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.
IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice.
Title: IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice.
IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes.
Title: IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-36 gamma

Names: IL-1F9; interleukin 1 family, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153511.3 → NP_705731.2 interleukin-36 gamma

See identical proteins and their annotated locations for NP_705731.2

Status: VALIDATED

Source sequence(s)

AK081783, BY778759

Consensus CDS

CCDS50518.1

UniProtKB/Swiss-Prot

Q14BB6, Q8R460

UniProtKB/TrEMBL

Q3U0P4

Related

ENSMUSP00000053391.3, ENSMUST00000057567.3

Conserved Domains (1) summary

cl00094
Location:89 → 180

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).