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    Slc43a2 solute carrier family 43, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 215113, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc43a2provided by MGI
    Official Full Name
    solute carrier family 43, member 2provided by MGI
    Primary source
    MGI:MGI:2442746
    See related
    Ensembl:ENSMUSG00000038178 AllianceGenome:MGI:2442746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lat4; 7630402D21Rik
    Summary
    Enables L-amino acid transmembrane transporter activity. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including adrenal medulla; metanephros; nephric duct of male; nervous system; and sensory organ. Orthologous to human SLC43A2 (solute carrier family 43 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 79.3), small intestine adult (RPKM 65.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 45.92 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75420741..75468401)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75529915..75577575)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7017 Neighboring gene scavenger receptor class F, member 1 Neighboring gene Rab interacting lysosomal protein Neighboring gene STARR-positive B cell enhancer ABC_E9036 Neighboring gene STARR-positive B cell enhancer ABC_E10689 Neighboring gene STARR-seq mESC enhancer starr_29997 Neighboring gene predicted gene 45606 Neighboring gene microRNA 3971 Neighboring gene STARR-positive B cell enhancer ABC_E10690 Neighboring gene STARR-positive B cell enhancer ABC_E9366 Neighboring gene STARR-positive B cell enhancer ABC_E9827 Neighboring gene STARR-positive B cell enhancer ABC_E9367 Neighboring gene RIKEN cDNA 4931413K12 gene Neighboring gene predicted gene, 53686 Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. Oparija-Rogenmozere L, et al. PLoS One, 2020. PMID 32470053, Free PMC Article
    2. Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development. Guetg A, et al. J Physiol, 2015 Mar 1. PMID 25480797, Free PMC Article
    3. Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. Oparija L, et al. J Physiol, 2019 Jan. PMID 30379325, Free PMC Article
    4. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Bian Y, et al. Nature, 2020 Sep. PMID 32879489, Free PMC Article
    5. Tissue-specific deletion of mouse basolateral uniporter LAT4 (Slc43a2) reveals its crucial role in small intestine and kidney amino acid transport. Rajendran A, et al. J Physiol, 2020 Nov. PMID 32841365, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
      Title: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
    2. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.
      Title: Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.
    3. LAT4 is subject to a circadian regulation by phosphorylation in the mouse small intestine, and this novel regulatory mechanism is suggested to play an important role in the diurnal regulation of amino acid absorption.
      Title: Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function.
    4. Mice lacking Lat4 display a slight intrauterine growth restriction, postnatal malnutrition and early death.
      Title: Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development.
    5. In situ hybridization experiments show that LAT4 mRNA is restricted to the epithelial cells of the distal tubule and the collecting duct in the kidney. In the intestine, LAT4 is mainly present in the cells of the crypt.
      Title: Identification of LAT4, a novel amino acid transporter with system L activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28931

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-isoleucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-leucine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-methionine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-phenylalanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-phenylalanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-alpha-amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within L-amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoleucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methionine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylalanine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large neutral amino acids transporter small subunit 4
    Names
    L-type amino L-acid transporter 4
    L-type amino acid transporter 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199283.1 → NP_001186212.1  large neutral amino acids transporter small subunit 4

      See identical proteins and their annotated locations for NP_001186212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AA017978, AK143773, AL591440, AL591496
      Consensus CDS
      CCDS25051.1
      UniProtKB/Swiss-Prot
      Q5CD76, Q8CGA3
      Related
      ENSMUSP00000126838.3, ENSMUST00000169547.9
      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    2. NM_001199284.1 → NP_001186213.1  large neutral amino acids transporter small subunit 4

      See identical proteins and their annotated locations for NP_001186213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment from its 5' UTR, compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AA017978, AB120363, AK143773, AL591440, BY202700
      Consensus CDS
      CCDS25051.1
      UniProtKB/Swiss-Prot
      Q5CD76, Q8CGA3
      Related
      ENSMUSP00000104071.2, ENSMUST00000108433.8
      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    3. NM_173388.2 → NP_775564.1  large neutral amino acids transporter small subunit 4

      See identical proteins and their annotated locations for NP_775564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different segment from its 5' UTR, compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AA017978, AK143773, AL591440, BY202700, CD550550
      Consensus CDS
      CCDS25051.1
      UniProtKB/Swiss-Prot
      Q5CD76, Q8CGA3
      Related
      ENSMUSP00000046074.8, ENSMUST00000042561.14
      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75420741..75468401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532825.4 → XP_006532888.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532888.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    2. XM_030245780.2 → XP_030101640.1  large neutral amino acids transporter small subunit 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5CD76, Q8CGA3
      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    3. XM_006532819.4 → XP_006532882.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532882.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    4. XM_006532827.5 → XP_006532890.1  large neutral amino acids transporter small subunit 4 isoform X2

      See identical proteins and their annotated locations for XP_006532890.1

      UniProtKB/Swiss-Prot
      Q5CD76, Q8CGA3
      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    5. XM_036156511.1 → XP_036012404.1  large neutral amino acids transporter small subunit 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5CD76, Q8CGA3
      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    6. XM_006532826.5 → XP_006532889.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532889.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    7. XM_006532820.4 → XP_006532883.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532883.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    8. XM_006532823.4 → XP_006532886.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532886.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    9. XM_006532821.4 → XP_006532884.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532884.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    10. XM_006532824.4 → XP_006532887.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532887.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    11. XM_006532822.5 → XP_006532885.1  large neutral amino acids transporter small subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006532885.1

      Conserved Domains (1) summary
      cd06174
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    12. XM_036156512.1 → XP_036012405.1  large neutral amino acids transporter small subunit 4 isoform X3

    RNA

    1. XR_003949380.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGA3.1 GenPept UniProtKB/Swiss-Prot:Q8CGA3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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