Chtf18 CTF18, chromosome transmission fidelity factor 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chtf18provided by MGI
Official Full Name: CTF18, chromosome transmission fidelity factor 18provided by MGI
Primary source: MGI:MGI:2384887
See related: Ensembl:ENSMUSG00000019214 AllianceGenome:MGI:2384887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTF18; Chl12; 6030457M03Rik
Summary: Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Acts upstream of or within cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 10.4), CNS E11.5 (RPKM 10.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.83 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25938004..25946409, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25719030..25727434, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHTF18 ensures the quantity and quality of the ovarian reservedagger.
Title: CHTF18 ensures the quantity and quality of the ovarian reserve†.
These findings demonstrate essential roles for CHTF18 in mammalian spermatogenesis and meiosis, and suggest that CHTF18 may function during the double-strand break repair pathway to promote the formation of crossovers.
Title: Disruption of CHTF18 causes defective meiotic recombination in male mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Chtf18 (e-PCR), detects polymorphism
- UniSTS:531045

Gng13 (e-PCR), detects polymorphism
- UniSTS:502770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA clamp loader activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA clamp loader activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to single-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chromosome transmission fidelity protein 18 homolog

Names: CTF18, chromosome transmission fidelity factor 18 homolog; Chl12 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145409.2 → NP_663384.2 chromosome transmission fidelity protein 18 homolog

See identical proteins and their annotated locations for NP_663384.2

Status: VALIDATED

Source sequence(s)

AK077947, BB861615, BC083096

Consensus CDS

CCDS28523.1

UniProtKB/Swiss-Prot

Q8BIW9, Q8R1R7

UniProtKB/TrEMBL

A0A0R4J0I4

Related

ENSMUSP00000043896.8, ENSMUST00000048054.14

Conserved Domains (2) summary

cd00009
Location:347 → 516

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

cl19912
Location:486 → 553

DNA_pol3_delta; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25938004..25946409 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524017.5 → XP_006524080.1 chromosome transmission fidelity protein 18 homolog isoform X1

UniProtKB/Swiss-Prot

Q8BIW9, Q8R1R7

UniProtKB/TrEMBL

E9PVJ3

Related

ENSMUSP00000131768.3, ENSMUST00000170070.3

Conserved Domains (1) summary

PRK04195
Location:343 → 589

PRK04195; replication factor C large subunit; Provisional
XM_030249640.2 → XP_030105500.1 chromosome transmission fidelity protein 18 homolog isoform X2

Conserved Domains (1) summary

PRK04195
Location:1 → 196

PRK04195; replication factor C large subunit; Provisional