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    Zfp879 zinc finger protein 879 [ Mus musculus (house mouse) ]

    Gene ID: 214779, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp879provided by MGI
    Official Full Name
    zinc finger protein 879provided by MGI
    Primary source
    MGI:MGI:3053099
    See related
    Ensembl:ENSMUSG00000044296 AllianceGenome:MGI:3053099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf879
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryo mesenchyme; genitourinary system; and limb segment. Orthologous to human ZNF879 (zinc finger protein 879). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 30.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50719821..50732414, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50828994..50841587, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 2 Neighboring gene predicted gene, 51860 Neighboring gene STARR-seq mESC enhancer starr_29408 Neighboring gene zinc finger protein 354C Neighboring gene STARR-positive B cell enhancer ABC_E6979 Neighboring gene glutamate receptor, metabotropic 6 Neighboring gene zinc finger protein 454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • 9630041N07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 879
    Names
    novel zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290779.1 → NP_001277708.1  zinc finger protein 879 isoform 2

      See identical proteins and their annotated locations for NP_001277708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK036152, BC118537, BF457823
      Consensus CDS
      CCDS70178.1
      UniProtKB/TrEMBL
      Q147Z4
      Related
      ENSMUSP00000104761.2, ENSMUST00000109133.2
      Conserved Domains (3) summary
      COG5048
      Location:132 → 485
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:453 → 478
      zf-H2C2_2; Zinc-finger double domain

    2. NM_173387.3 → NP_775563.1  zinc finger protein 879 isoform 1

      See identical proteins and their annotated locations for NP_775563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK036152, BF457823
      Consensus CDS
      CCDS24638.1
      UniProtKB/Swiss-Prot
      Q8BI99
      Related
      ENSMUSP00000061782.2, ENSMUST00000049625.2
      Conserved Domains (6) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:205 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:204 → 226
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:526 → 551
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50719821..50732414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245779.1 → XP_030101639.1  zinc finger protein 879 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:201 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:370 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI99.1 GenPept UniProtKB/Swiss-Prot:Q8BI99

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