Slc25a29 solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a29provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29provided by MGI
Primary source: MGI:MGI:2444911
See related: Ensembl:ENSMUSG00000021265 AllianceGenome:MGI:2444911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CACL; mCACL; C030003J19Rik
Summary: Enables acyl carnitine transmembrane transporter activity and basic amino acid transmembrane transporter activity. Involved in mitochondrial L-ornithine transmembrane transport. Acts upstream of or within acyl carnitine transport. Located in mitochondrion. Orthologous to human SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 45.1), genital fat pad adult (RPKM 17.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 59.62 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (108791804..108801802, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (108825878..108835876, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human and mouse SLC25A29 mitochondrial ornithine transporters (designated as ORNT3) rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.
Title: The human and mouse SLC25A29 mitochondrial transporters rescue the deficient ornithine metabolism in fibroblasts of patients with the hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a29 (e-PCR), detects polymorphism
- UniSTS:547048

BB316109 (e-PCR)
- UniSTS:208874

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl carnitine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables basic amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables basic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-arginine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables high-affinity L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity lysine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-lysine transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within acyl carnitine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within acyl carnitine transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial L-ornithine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial L-ornithine transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ornithine transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial basic amino acids transporter

Names: carnitine/acylcarnitine translocase-like; mitochondrial carnitine/acylcarnitine carrier protein CACL; mitochondrial ornithine transporter 3; solute carrier family 25 member 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181328.3 → NP_851845.1 mitochondrial basic amino acids transporter

See identical proteins and their annotated locations for NP_851845.1

Status: PROVISIONAL

Source sequence(s)

AK047628

Consensus CDS

CCDS26164.1

UniProtKB/Swiss-Prot

Q8BL03, Q922X4

Related

ENSMUSP00000021693.4, ENSMUST00000021693.4

Conserved Domains (2) summary

PTZ00169
Location:2 → 259

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:88 → 175

Mito_carr; Mitochondrial carrier protein