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    Pstk phosphoseryl-tRNA kinase [ Mus musculus (house mouse) ]

    Gene ID: 214580, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pstkprovided by MGI
    Official Full Name
    phosphoseryl-tRNA kinaseprovided by MGI
    Primary source
    MGI:MGI:2685945
    See related
    Ensembl:ENSMUSG00000063179 AllianceGenome:MGI:2685945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1099; 5430423O14Rik; 5730458D16Rik
    Summary
    Enables L-seryl-tRNA(Sec) kinase activity and tRNA binding activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Orthologous to human PSTK (phosphoseryl-tRNA kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.3), adrenal adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 73.94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130972843..130994497)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131371113..131392768)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310057M21 gene Neighboring gene family with sequence similarity 24, member A Neighboring gene STARR-positive B cell enhancer ABC_E9713 Neighboring gene STARR-positive B cell enhancer ABC_E8214 Neighboring gene STARR-seq mESC enhancer starr_20280 Neighboring gene STARR-seq mESC enhancer starr_20281 Neighboring gene IKAROS family zinc finger 5 Neighboring gene STARR-positive B cell enhancer ABC_E4981 Neighboring gene acyl-Coenzyme A dehydrogenase, short/branched chain Neighboring gene motile sperm domain containing 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression profile analysis of PSTK-regulated mRNAs in podocytes. Zheng D, et al. J Cell Biochem, 2019 Jun. PMID 28419530
    2. PSTK is a novel gene associated with early lung injury in Paraquat Poisoning. Zheng D, et al. Life Sci, 2015 Feb 15. PMID 25592138
    3. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Carlson BA, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15317934, Free PMC Article
    4. hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Ye J, et al. Proc Natl Acad Sci U S A, 2015 Jun 9. PMID 26039991, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified a set of candidate genes that are putatively regulated by PSTK in podocytes.
      Title: Differential expression profile analysis of PSTK-regulated mRNAs in podocytes.
    2. PSTK is a novel gene associated with early lung injury in Paraquat Poisoning.
      Title: PSTK is a novel gene associated with early lung injury in Paraquat Poisoning.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-seryl-tRNA(Sec) kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    L-seryl-tRNA(Sec) kinase
    Names
    O-phosphoseryl-tRNA(Sec) kinase
    NP_001034623.1
    NP_001351090.1
    XP_006507618.1
    XP_006507620.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039534.1 → NP_001034623.1  L-seryl-tRNA(Sec) kinase isoform 1

      See identical proteins and their annotated locations for NP_001034623.1

      Status: VALIDATED

      Source sequence(s)
      AI173292, AK077585, AU255311, AV333054
      Consensus CDS
      CCDS21914.1
      UniProtKB/Swiss-Prot
      Q0D2I7, Q14C09, Q8BP74
      Related
      ENSMUSP00000075037.7, ENSMUST00000075610.13
      Conserved Domains (2) summary
      TIGR03575
      Location:20 → 358
      selen_PSTK_euk; L-seryl-tRNA(Sec) kinase, eukaryotic
      pfam08433
      Location:20 → 343
      KTI12; Chromatin associated protein KTI12

    2. NM_001364161.1 → NP_001351090.1  L-seryl-tRNA(Sec) kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156606
      Conserved Domains (1) summary
      cl17190
      Location:20 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      130972843..130994497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507555.5 → XP_006507618.1  L-seryl-tRNA(Sec) kinase isoform X1

      See identical proteins and their annotated locations for XP_006507618.1

      Conserved Domains (1) summary
      cl17190
      Location:20 → 294
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_006507557.5 → XP_006507620.1  L-seryl-tRNA(Sec) kinase isoform X2

      Related
      ENSMUSP00000118636.2, ENSMUST00000145114.8
      Conserved Domains (1) summary
      cl17190
      Location:20 → 262
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177609.2: Suppressed sequence

      Description
      NM_177609.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP74.2 GenPept UniProtKB/Swiss-Prot:Q8BP74

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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