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    Gm4787 predicted gene 4787 [ Mus musculus (house mouse) ]

    Gene ID: 214321, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gm4787provided by MGI
    Official Full Name
    predicted gene 4787provided by MGI
    Primary source
    MGI:MGI:3646380
    See related
    Ensembl:ENSMUSG00000072974 AllianceGenome:MGI:3646380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adam4b; EG214321
    Summary
    Predicted to be involved in male gonad development. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    12 D1; 12 37.62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81423765..81426260, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81376991..81379486, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53730 Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene cytochrome c oxidase assembly protein 16 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene a disintegrin and metallopeptidase domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    2. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    3. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metalloprotease domain 4b
    Names
    a disintegrin and metallopeptidase domain 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038995.2 → NP_001034084.2  a disintegrin and metalloprotease domain 4b precursor

      See identical proteins and their annotated locations for NP_001034084.2

      Status: VALIDATED

      Source sequence(s)
      AC132391, BQ129905, CJ047802
      Consensus CDS
      CCDS26018.1
      UniProtKB/TrEMBL
      B2RUD9, Q6IMH8
      Related
      ENSMUSP00000077390.6, ENSMUST00000062182.8
      Conserved Domains (4) summary
      smart00608
      Location:501 → 642
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213 → 405
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:425 → 498
      Disintegrin; Disintegrin
      pfam01562
      Location:60 → 163
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81423765..81426260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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