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    Tcea3 transcription elongation factor A (SII), 3 [ Mus musculus (house mouse) ]

    Gene ID: 21401, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tcea3provided by MGI
    Official Full Name
    transcription elongation factor A (SII), 3provided by MGI
    Primary source
    MGI:MGI:1196908
    See related
    Ensembl:ENSMUSG00000001604 AllianceGenome:MGI:1196908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S-II; SII-K1
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including apical ectodermal ridge; early conceptus; genitourinary system; retina; and tongue. Orthologous to human TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 16.7), heart adult (RPKM 13.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 68.34 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135975253..136002214)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136247936..136274903)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135727983-135728166 Neighboring gene STARR-positive B cell enhancer ABC_E3530 Neighboring gene STARR-seq mESC enhancer starr_11747 Neighboring gene STARR-positive B cell enhancer ABC_E6237 Neighboring gene STARR-positive B cell enhancer ABC_E427 Neighboring gene E2F transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_11748 Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene zinc finger protein 46 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription elongation factor TCEA3 promotes the activity of the myogenic regulatory factors. Kazim N, et al. PLoS One, 2019. PMID 31158246, Free PMC Article
    2. Tcea3 regulates the vascular differentiation potential of mouse embryonic stem cells. Cha Y, et al. Gene Expr, 2013. PMID 24397209, Free PMC Article
    3. Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice. Tano K, et al. Drug Discov Ther, 2010 Oct. PMID 22491241
    4. Molecular cloning of cDNA and tissue-specific expression of the gene for SII-K1, a novel transcription elongation factor SII. Taira Y, et al. Genes Cells, 1998 May. PMID 9685180
    5. Transcription factor genes and the developing eye: a genetic perspective. Freund C, et al. Hum Mol Genet, 1996. PMID 8875254

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. which is located in the cytoplasm and also promotes cell differentiation. Collectively, our results indicate that TCEA3 promotes cell differentiation by interacting with ANXA1 and affecting transforming growth factor-b signaling pathways
      Title: TCEA3 promotes differentiation of C2C12 cells via an Annexin A1-mediated transforming growth factor-β signaling pathway.
    2. TCEA3 is a required co-factor for myogenic regulatory factors driven gene expression during myogenesis.
      Title: The transcription elongation factor TCEA3 promotes the activity of the myogenic regulatory factors.
    3. Vascular endothelial growth factor A and VEGFC, major transcription factors that regulate vasculogenesis, are activated in Tcea3 knocked down mESCs
      Title: Tcea3 regulates the vascular differentiation potential of mouse embryonic stem cells.
    4. Tcea3 critically regulates pluripotent differentiation of mouse embryonic stem cells as a molecular rheostat of Lefty1-Nodal-Smad2 signaling.
      Title: Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway.
    5. These results suggest that S-II is involved in transcription of the Bcl-x and beta(major)-globin gene during erythroblast differentiation, by relieving transcription arrest or affecting histone modification on chromatin template.
      Title: Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation.
    6. S-II is required for definitive hematopoiesis.
      Title: Transcription elongation factor S-II is required for definitive hematopoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription elongation factor A protein 3
    Names
    tissue-specific transcription factor S-II
    transcription elongation factor S-II protein 3
    transcription elongation factor TFIIS.h

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011542.2 → NP_035672.1  transcription elongation factor A protein 3

      See identical proteins and their annotated locations for NP_035672.1

      Status: VALIDATED

      Source sequence(s)
      AK002319, AK007437
      Consensus CDS
      CCDS18803.1
      UniProtKB/Swiss-Prot
      A2AW46, O88710, P23881, Q9CTZ8, Q9DCZ5
      UniProtKB/TrEMBL
      A8CA96
      Related
      ENSMUSP00000099592.5, ENSMUST00000102533.11
      Conserved Domains (4) summary
      smart00510
      Location:184 → 285
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd00183
      Location:4 → 80
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:300 → 346
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:5 → 347
      TFSII; transcription elongation factor S-II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135975253..136002214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538710.5 → XP_006538773.1  transcription elongation factor A protein 3 isoform X1

      UniProtKB/TrEMBL
      A8CA96
      Conserved Domains (1) summary
      TIGR01385
      Location:5 → 385
      TFSII; transcription elongation factor S-II

    2. XM_006538712.5 → XP_006538775.1  transcription elongation factor A protein 3 isoform X3

      UniProtKB/TrEMBL
      A8CA96
      Conserved Domains (1) summary
      TIGR01385
      Location:5 → 361
      TFSII; transcription elongation factor S-II

    3. XM_006538711.5 → XP_006538774.1  transcription elongation factor A protein 3 isoform X2

      UniProtKB/TrEMBL
      A8CA96
      Conserved Domains (1) summary
      TIGR01385
      Location:5 → 371
      TFSII; transcription elongation factor S-II
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23881.3 GenPept UniProtKB/Swiss-Prot:P23881

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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