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    Tbxa2r thromboxane A2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 21390, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tbxa2rprovided by MGI
    Official Full Name
    thromboxane A2 receptorprovided by MGI
    Primary source
    MGI:MGI:98496
    See related
    Ensembl:ENSMUSG00000034881 AllianceGenome:MGI:98496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TP; TXA2-R
    Summary
    This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in thymus adult (RPKM 81.0), adrenal adult (RPKM 54.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81164102..81171008)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81328268..81335174)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Neighboring gene predicted gene 16315 Neighboring gene cactin, spliceosome C complex subunit Neighboring gene GIPC PDZ domain containing family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1809 Neighboring gene high mobility group 20B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm. Matsuda H, et al. Arterioscler Thromb Vasc Biol, 2021 Apr. PMID 33567865
    2. TP and/or EP3 receptors mediate the vasoconstrictor and pressor responses of prostaglandin F(2α) in mice and/or humans. Liu B, et al. FASEB J, 2019 Feb. PMID 30277822
    3. Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo. Shen Y, et al. Circ Res, 2016 Apr 15. PMID 26957525
    4. Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity. Minamino T, et al. Life Sci, 2015 Jul 1. PMID 25921763
    5. Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries. Siangjong L, et al. Am J Physiol Heart Circ Physiol, 2013 Feb 1. PMID 23203967, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
      Title: Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
    2. Deletion of vascular thromboxane A2 receptors and its impact on angiotensin II-induced hypertension and atherosclerotic lesion formation in the aorta of Ldlr-deficient mice.
      Title: Deletion of vascular thromboxane A(2) receptors and its impact on angiotensin II-induced hypertension and atherosclerotic lesion formation in the aorta of Ldlr-deficient mice.
    3. Inhibition of TP signaling promotes endometriosis growth and neovascularization.
      Title: Inhibition of TP signaling promotes endometriosis growth and neovascularization.
    4. Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm.
      Title: Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm.
    5. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
      Title: Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
    6. PGF2alpha potentiates platelet aggregation in vitro via EP3 receptor and thromboxane A2 receptor, but not PGF2a receptor
      Title: Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice.
    7. this study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury
      Title: Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury.
    8. The results suggest that EP3 along with TP contributes to vasoconstrictor responses evoked by PGI2, and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2) in regulating vascular functions.
      Title: Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice.
    9. platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation
      Title: GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.
    10. Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.
      Title: Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107665

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thromboxane receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thromboxane receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of vasoconstriction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thromboxane A2 receptor
    Names
    TXA2 receptor
    prostanoid TP receptor
    thromboxane prostanoid

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277265.1 → NP_001264194.1  thromboxane A2 receptor

      See identical proteins and their annotated locations for NP_001264194.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC155937, AI841195, AK158477
      Consensus CDS
      CCDS24053.1
      UniProtKB/Swiss-Prot
      P30987
      UniProtKB/TrEMBL
      Q5FW61
      Related
      ENSMUSP00000100962.3, ENSMUST00000105325.4
      Conserved Domains (2) summary
      cd14964
      Location:27 → 51
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001358512.1 → NP_001345441.1  thromboxane A2 receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC155937, AI841195, AK158477, BC138885
      Consensus CDS
      CCDS24053.1
      UniProtKB/Swiss-Prot
      P30987
      UniProtKB/TrEMBL
      Q5FW61
      Conserved Domains (2) summary
      cd14964
      Location:27 → 51
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_009325.4 → NP_033351.1  thromboxane A2 receptor

      See identical proteins and their annotated locations for NP_033351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC155937, AI841195, AK158477, BC138885
      Consensus CDS
      CCDS24053.1
      UniProtKB/Swiss-Prot
      P30987
      UniProtKB/TrEMBL
      Q5FW61
      Related
      ENSMUSP00000151447.2, ENSMUST00000220312.2
      Conserved Domains (2) summary
      cd14964
      Location:27 → 51
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81164102..81171008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30987.1 GenPept UniProtKB/Swiss-Prot:P30987

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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