U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Cracr2b calcium release activated channel regulator 2B [ Mus musculus (house mouse) ]

    Gene ID: 213573, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cracr2bprovided by MGI
    Official Full Name
    calcium release activated channel regulator 2Bprovided by MGI
    Primary source
    MGI:MGI:2446129
    See related
    Ensembl:ENSMUSG00000048200 AllianceGenome:MGI:2446129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Efcab4; Cracr2a; Efcab4a; 6330520A15Rik
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within regulation of store-operated calcium entry. Located in cytoplasm. Orthologous to human CRACR2B (calcium release activated channel regulator 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 35.7), colon adult (RPKM 21.5) and 13 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    7 F5; 7 86.82 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141041007..141046526)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141460875..141466613)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene predicted gene 10575 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cracking CRAC. Carrasco S, et al. Nat Cell Biol, 2010 May. PMID 20442700, Free PMC Article
    2. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Srikanth S, et al. Nat Cell Biol, 2010 May. PMID 20418871, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of store-operated calcium entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    EF-hand calcium-binding domain-containing protein 4A
    Names
    EF-hand calcium binding domain 4A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025103.2 → NP_001020274.2  EF-hand calcium-binding domain-containing protein 4A

      See identical proteins and their annotated locations for NP_001020274.2

      Status: VALIDATED

      Source sequence(s)
      BC048916
      Consensus CDS
      CCDS22016.1
      UniProtKB/Swiss-Prot
      Q4KMV3, Q80ZJ8, Q8R0L0
      Related
      ENSMUSP00000055899.6, ENSMUST00000053670.12
      Conserved Domains (2) summary
      PRK12309
      Location:26 → 92
      PRK12309; transaldolase
      TIGR02168
      Location:168 → 322
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141041007..141046526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536174.3 → XP_006536237.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006536237.1

      UniProtKB/Swiss-Prot
      Q4KMV3, Q80ZJ8, Q8R0L0
      Conserved Domains (2) summary
      PRK12309
      Location:26 → 92
      PRK12309; transaldolase
      TIGR02168
      Location:168 → 322
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_036152881.1 → XP_036008774.1  EF-hand calcium-binding domain-containing protein 4A isoform X2

      Conserved Domains (2) summary
      PRK12309
      Location:26 → 92
      PRK12309; transaldolase
      COG1196
      Location:158 → 336
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_036152880.1 → XP_036008773.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      UniProtKB/Swiss-Prot
      Q4KMV3, Q80ZJ8, Q8R0L0
      Conserved Domains (2) summary
      PRK12309
      Location:26 → 92
      PRK12309; transaldolase
      TIGR02168
      Location:168 → 322
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZJ8.2 GenPept UniProtKB/Swiss-Prot:Q80ZJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous