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    Pth2r parathyroid hormone 2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 213527, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pth2rprovided by MGI
    Official Full Name
    parathyroid hormone 2 receptorprovided by MGI
    Primary source
    MGI:MGI:2180917
    See related
    Ensembl:ENSMUSG00000025946 AllianceGenome:MGI:2180917
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pthr2
    Summary
    Predicted to enable G protein-coupled peptide receptor activity; parathyroid hormone receptor activity; and peptide hormone binding activity. Involved in positive regulation of cold-induced thermogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PTH2R (parathyroid hormone 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C3; 1 33.05 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65317921..65428784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65280282..65389625)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65224921-65225030 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65225772-65225881 Neighboring gene STARR-positive B cell enhancer ABC_E5765 Neighboring gene isocitrate dehydrogenase 1 (NADP+), soluble Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene STARR-positive B cell enhancer ABC_E5766 Neighboring gene STARR-seq mESC enhancer starr_01177 Neighboring gene STARR-seq mESC enhancer starr_01178 Neighboring gene STARR-seq mESC enhancer starr_01179 Neighboring gene predicted gene 28926 Neighboring gene predicted gene 28923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice. Gellén B, et al. Physiol Behav, 2017 Nov 1. PMID 28890271
    2. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. Tsuda MC, et al. J Neurosci, 2015 Sep 2. PMID 26338326, Free PMC Article
    3. Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. Panda DK, et al. Am J Physiol Endocrinol Metab, 2012 Dec 15. PMID 23092913, Free PMC Article
    4. Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release. Atchison DK, et al. Am J Physiol Renal Physiol, 2012 Oct 15. PMID 22896038, Free PMC Article
    5. Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development. Coutellier L, et al. J Neuroendocrinol, 2011 Jul. PMID 21535248, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice.
      Title: The parathyroid hormone 2 receptor participates in physiological and behavioral alterations of mother mice.
    2. Data indicate that the nociceptive phenotype of TIP39-knockout {KO) mice was similar to the PTH2R-KO.
      Title: Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.
    3. Data suggest a role for Pth2r signaling in postnatal growth plate development and subsequent bone mass acquisition.
      Title: Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor.
    4. Involvement of the TIP39/PTH2-R system in the pathways involved in the successful development of the pups.
      Title: Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development.
    5. We propose that TIP39 is an endogenous ligand of the PTH2R and that they form a neuromodulator system, which is optimally positioned to regulate limbic, endocrine, and auditory brain functions.
      Title: Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables parathyroid hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables parathyroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    parathyroid hormone 2 receptor
    Names
    PTH2 receptor
    parathyroid hormone receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139270.2 → NP_644676.1  parathyroid hormone 2 receptor precursor

      See identical proteins and their annotated locations for NP_644676.1

      Status: PROVISIONAL

      Source sequence(s)
      AK045576
      Consensus CDS
      CCDS15017.1
      UniProtKB/Swiss-Prot
      Q91V95
      Related
      ENSMUSP00000027083.7, ENSMUST00000027083.7
      Conserved Domains (2) summary
      pfam00002
      Location:139 → 406
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:63 → 125
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65317921..65428784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238473.2 → XP_011236775.1  parathyroid hormone 2 receptor isoform X1

      Conserved Domains (3) summary
      cd14964
      Location:136 → 161
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02793
      Location:58 → 120
      HRM; Hormone receptor domain
      cl28897
      Location:134 → 422
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_011238474.4 → XP_011236776.1  parathyroid hormone 2 receptor isoform X2

      See identical proteins and their annotated locations for XP_011236776.1

      Conserved Domains (3) summary
      cd14964
      Location:100 → 125
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02793
      Location:22 → 84
      HRM; Hormone receptor domain
      cl28897
      Location:98 → 386
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_017319688.2 → XP_017175177.1  parathyroid hormone 2 receptor isoform X5

      Conserved Domains (3) summary
      cd14964
      Location:141 → 166
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02793
      Location:63 → 125
      HRM; Hormone receptor domain
      cl28897
      Location:139 → 324
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_006495842.2 → XP_006495905.1  parathyroid hormone 2 receptor isoform X2

      See identical proteins and their annotated locations for XP_006495905.1

      Conserved Domains (3) summary
      cd14964
      Location:100 → 125
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02793
      Location:22 → 84
      HRM; Hormone receptor domain
      cl28897
      Location:98 → 386
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_017319687.1 → XP_017175176.1  parathyroid hormone 2 receptor isoform X3

      Conserved Domains (3) summary
      cd14964
      Location:86 → 111
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02793
      Location:8 → 70
      HRM; Hormone receptor domain
      cl28897
      Location:84 → 372
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_006495843.4 → XP_006495906.1  parathyroid hormone 2 receptor isoform X4

      Conserved Domains (3) summary
      cd14964
      Location:61 → 86
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02793
      Location:1 → 45
      HRM; Hormone receptor domain
      cl28897
      Location:59 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V95.1 GenPept UniProtKB/Swiss-Prot:Q91V95

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