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    Klhdc8a kelch domain containing 8A [ Mus musculus (house mouse) ]

    Gene ID: 213417, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhdc8aprovided by MGI
    Official Full Name
    kelch domain containing 8Aprovided by MGI
    Primary source
    MGI:MGI:2442630
    See related
    Ensembl:ENSMUSG00000042115 AllianceGenome:MGI:2442630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630065K24Rik
    Summary
    Is expressed in adrenal cortex; central nervous system; metanephros; neural retina; and trigeminal nerve. Orthologous to human KLHDC8A (kelch domain containing 8A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 84.1), cerebellum adult (RPKM 7.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E4; 1 57.24 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132226352..132236216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132298490..132307357)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02242 Neighboring gene predicted gene 29630 Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241 Neighboring gene STARR-positive B cell enhancer ABC_E2009 Neighboring gene STARR-seq mESC enhancer starr_02251 Neighboring gene NUAK family, SNF1-like kinase, 2 Neighboring gene predicted gene, 30744 Neighboring gene VISTA enhancer mm505 Neighboring gene RIKEN cDNA F730311O21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7749 Neighboring gene STARR-positive B cell enhancer ABC_E11087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Ota M, et al. Development, 2008 Dec. PMID 19004856
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC19056

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417652.1 → NP_001404581.1  kelch domain-containing protein 8A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160545

    2. NM_144810.6 → NP_659059.1  kelch domain-containing protein 8A isoform 1

      See identical proteins and their annotated locations for NP_659059.1

      Status: VALIDATED

      Source sequence(s)
      AC160545
      Consensus CDS
      CCDS35706.1
      UniProtKB/Swiss-Prot
      Q91XA8
      UniProtKB/TrEMBL
      Q8C939
      Related
      ENSMUSP00000038297.5, ENSMUST00000046071.5
      Conserved Domains (2) summary
      PHA03098
      Location:5 → 209
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:21 → 65
      Kelch; KELCH repeat [structural motif]

    RNA

    1. NR_184552.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC160545

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132226352..132236216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529354.5 → XP_006529417.1  kelch domain-containing protein 8A isoform X1

      See identical proteins and their annotated locations for XP_006529417.1

      UniProtKB/Swiss-Prot
      Q91XA8
      UniProtKB/TrEMBL
      Q8C939
      Conserved Domains (2) summary
      PHA03098
      Location:5 → 209
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:21 → 65
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XA8.1 GenPept UniProtKB/Swiss-Prot:Q91XA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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