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    Taf1a TATA-box binding protein associated factor, RNA polymerase I, A [ Mus musculus (house mouse) ]

    Gene ID: 21339, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Taf1aprovided by MGI
    Official Full Name
    TATA-box binding protein associated factor, RNA polymerase I, Aprovided by MGI
    Primary source
    MGI:MGI:109578
    See related
    Ensembl:ENSMUSG00000072258 AllianceGenome:MGI:109578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAFI48; mTAFI48
    Summary
    Predicted to enable DNA binding activity. Predicted to act upstream of or within transcription by RNA polymerase I. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be part of RNA polymerase I transcription regulator complex. Orthologous to human TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.3), bladder adult (RPKM 6.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1; 1 H5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183170251..183195776)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183388885..183410201)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene hedgehog interacting protein-like 2 Neighboring gene predicted gene, 33973 Neighboring gene STARR-seq mESC enhancer starr_03295 Neighboring gene predicted gene, 39724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex. Murano K, et al. J Cell Sci, 2014 Aug 1. PMID 24928901
    2. Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. Heix J, et al. Proc Natl Acad Sci U S A, 1997 Mar 4. PMID 9050847, Free PMC Article
    3. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto K, et al. Mol Cell Biol, 2004 Jul. PMID 15226435, Free PMC Article
    4. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
    5. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within transcription by RNA polymerase I TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I transcription regulator complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of RNA polymerase transcription factor SL1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of RNA polymerase transcription factor SL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TATA box-binding protein-associated factor RNA polymerase I subunit A
    Names
    RNA polymerase I-specific TBP-associated factor 48 kDa
    TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
    TATA box-binding protein-associated factor 1A
    TBP-associated factor 1A
    transcription initiation factor SL1/TIF-IB subunit A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277957.2 → NP_001264886.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

      See identical proteins and their annotated locations for NP_001264886.1

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108034, LXEJ02002843
      UniProtKB/TrEMBL
      B9EHT7, Q3V054
      Conserved Domains (1) summary
      pfam14929
      Location:64 → 411
      TAF1_subA; TAF RNA Polymerase I subunit A

    2. NM_001277958.2 → NP_001264887.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108034, LXEJ02002843
      UniProtKB/TrEMBL
      Q3V054
      Conserved Domains (1) summary
      pfam14929
      Location:9 → 451
      TAF1_subA; TAF RNA Polymerase I subunit A

    3. NM_001277959.2 → NP_001264888.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1

      See identical proteins and their annotated locations for NP_001264888.1

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108034, LXEJ02002843
      UniProtKB/Swiss-Prot
      P97357
      UniProtKB/TrEMBL
      Q3V054
      Related
      ENSMUSP00000142213.3, ENSMUST00000192076.3
      Conserved Domains (1) summary
      pfam14929
      Location:9 → 444
      TAF1_subA; TAF RNA Polymerase I subunit A

    4. NM_001420538.1 → NP_001407467.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108034, LXEJ02002843
      UniProtKB/TrEMBL
      B9EHT7

    5. NM_021466.4 → NP_067441.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1

      See identical proteins and their annotated locations for NP_067441.1

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108034, LXEJ02002843
      UniProtKB/Swiss-Prot
      P97357
      UniProtKB/TrEMBL
      Q3V054
      Conserved Domains (1) summary
      pfam14929
      Location:9 → 444
      TAF1_subA; TAF RNA Polymerase I subunit A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      183170251..183195776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004941413.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97357.1 GenPept UniProtKB/Swiss-Prot:P97357

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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