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    T2 brachyury 2 [ Mus musculus (house mouse) ]

    Gene ID: 21331, updated on 8-Feb-2024

    Summary

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    Official Symbol
    T2provided by MGI
    Official Full Name
    brachyury 2provided by MGI
    Primary source
    MGI:MGI:104658
    See related
    Ensembl:ENSMUSG00000058159 AllianceGenome:MGI:104658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    brachyury2
    Summary
    Acts upstream of or within notochord formation. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 1.1), lung adult (RPKM 0.9) and 12 other tissues See more
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    Genomic context

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    Location:
    17 A1; 17 4.92 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (8574590..8661323)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (8355760..8422728)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930506C21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8503785-8503968 Neighboring gene SFT2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8564858-8564967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8565311-8565494 Neighboring gene STARR-positive B cell enhancer ABC_E4191 Neighboring gene predicted gene, 46592 Neighboring gene proline rich 18 Neighboring gene STARR-seq mESC enhancer starr_41764 Neighboring gene protein FAM32A pseudogene Neighboring gene predicted gene, 16702 Neighboring gene STARR-seq mESC enhancer starr_41765 Neighboring gene T (brachyury) promoter Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene, 34036 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8661752-8661935 Neighboring gene brachyury, T-box transcription factor T Neighboring gene STARR-seq mESC enhancer starr_41767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:8755802-8755955 Neighboring gene phosphodiesterase 10A Neighboring gene predicted gene 15425 Neighboring gene predicted gene 17087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct. Rennebeck G, et al. Genetics, 1998 Nov. PMID 9799264, Free PMC Article
    2. Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. Wu JI, et al. Genetics, 2007 Oct. PMID 17954925, Free PMC Article
    3. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Rennebeck GM, et al. Dev Biol, 1995 Nov. PMID 7589801
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within notochord formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    brachyury 2
    Names
    brachyury the second

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161832.1 → NP_001155304.1  brachyury 2

      See identical proteins and their annotated locations for NP_001155304.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154579, AC164431
      Consensus CDS
      CCDS88987.1
      UniProtKB/TrEMBL
      A0A338P791
      Related
      ENSMUSP00000156321.2, ENSMUST00000163578.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      8574590..8661323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160447.1 → XP_036016340.1  brachyury 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q4EGG8
      Related
      ENSMUSP00000157191.2, ENSMUST00000234809.2

    2. XM_036160444.1 → XP_036016337.1  brachyury 2 isoform X1

      Conserved Domains (1) summary
      cd20202
      Location:41 → 219
      T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins

    3. XM_036160445.1 → XP_036016338.1  brachyury 2 isoform X2

      UniProtKB/Swiss-Prot
      P20293
      UniProtKB/TrEMBL
      Q78ZW9
      Conserved Domains (1) summary
      cd20202
      Location:41 → 219
      T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins

    4. XM_036160449.1 → XP_036016342.1  brachyury 2 isoform X4

    5. XM_036160448.1 → XP_036016341.1  brachyury 2 isoform X4

    RNA

    1. XR_004939491.1 RNA Sequence

    2. XR_004939489.1 RNA Sequence

    3. XR_004939490.1 RNA Sequence

    4. XR_004939496.1 RNA Sequence

    5. XR_004939498.1 RNA Sequence

    6. XR_004939497.1 RNA Sequence

    7. XR_004939487.1 RNA Sequence

    8. XR_004939492.1 RNA Sequence

    9. XR_004939493.1 RNA Sequence

    10. XR_004939494.1 RNA Sequence

    11. XR_004939495.1 RNA Sequence

    12. XR_004939502.1 RNA Sequence

    13. XR_004939488.1 RNA Sequence

    14. XR_004939504.1 RNA Sequence

    15. XR_004939500.1 RNA Sequence

      Related
      ENSMUST00000169635.3

    16. XR_004939499.1 RNA Sequence

    17. XR_004939501.1 RNA Sequence

    18. XR_004939503.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013682.1: Suppressed sequence

      Description
      NM_013682.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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