Dnd1 DND microRNA-mediated repression inhibitor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnd1provided by MGI
Official Full Name: DND microRNA-mediated repression inhibitor 1provided by MGI
Primary source: MGI:MGI:2447763
See related: Ensembl:ENSMUSG00000044595 AllianceGenome:MGI:2447763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ter; RBMS4
Summary: Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within germ cell development. Located in cytoplasm. Is expressed in several structures, including allantois; central nervous system; gonad; head mesenchyme; and sensory organ. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 10.8), ovary adult (RPKM 7.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (36896724..36899267, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (36763671..36766214, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.
Title: Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.
Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes.
Title: Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes.
The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.
Title: The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.
A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
Title: A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cellsdagger.
Title: A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
Dnd1 loss caused defects in both spermatogenesis and oogenesis and results in testicular teratoma incidence.
Title: Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.
Results suggest multiple DND1 functions and link DND1 to initiation of epigenetic modifications in male germ cells.
Title: The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
Cultured Dead-end1 (Dnd1) mutant germ cells (CDGCs) were morphologically similar to embryonic stem cells (ESCs) and could be maintained in the naive pluripotent condition.
Title: Derivation of pluripotent stem cells from nascent undifferentiated teratoma.
DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase complex.
Title: DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
DND1 interacts with NANOS2 to load unique RNAs into the CCR4-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2, which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 that leads to the degradation of specific RNAs in male germ cell development
Title: Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:471090 (e-PCR)
- UniSTS:471090

Dnd1 (e-PCR), detects polymorphism
- UniSTS:471090

C80692 (e-PCR)
- UniSTS:181088

Dnd1 (e-PCR), detects polymorphism
- UniSTS:479099

Hars (e-PCR), detects polymorphism
- UniSTS:143316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dead end protein homolog 1

Names: RNA-binding motif, single-stranded-interacting protein 4; dead end homolog 1; teratoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173383.2 → NP_775559.2 dead end protein homolog 1

See identical proteins and their annotated locations for NP_775559.2

Status: VALIDATED

Source sequence(s)

AY321066, BC034897

Consensus CDS

CCDS29163.2

UniProtKB/Swiss-Prot

Q6VY05, Q8CFK7

Related

ENSMUSP00000054412.8, ENSMUST00000061522.8

Conserved Domains (3) summary

cd12487
Location:57 → 134

RRM1_DND1; RNA recognition motif 1 found in vertebrate dead end protein homolog 1 (DND1)

pfam14709
Location:253 → 333

DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1

cl17169
Location:136 → 218

RRM_SF; RNA recognition motif (RRM) superfamily