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    Hycc2 hyccin PI4KA lipid kinase complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 213056, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hycc2provided by MGI
    Official Full Name
    hyccin PI4KA lipid kinase complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1098784
    See related
    Ensembl:ENSMUSG00000038174 AllianceGenome:MGI:1098784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam126b; D1Ertd53e; D630010C10; C130065N10Rik
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Orthologous to human FAM126B (family with sequence similarity 126 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 5.3), cerebellum adult (RPKM 5.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.3; 1 29.12 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58561965..58625492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58522806..58586333, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene origin recognition complex, subunit 2 Neighboring gene STARR-seq mESC enhancer starr_01014 Neighboring gene STARR-positive B cell enhancer ABC_E3277 Neighboring gene STARR-seq mESC enhancer starr_01015 Neighboring gene predicted gene 15834 Neighboring gene STARR-positive B cell enhancer ABC_E10012 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene STARR-seq mESC enhancer starr_01016 Neighboring gene Fanconi anemia, complementation group L pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hyccin 2
    Names
    family with sequence similarity 126, member B
    protein FAM126B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310598.1 → NP_001297527.1  hyccin 2 isoform a

      See identical proteins and their annotated locations for NP_001297527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC118698, AK168372, CA556879
      Consensus CDS
      CCDS78588.1
      UniProtKB/Swiss-Prot
      Q8C729
      Related
      ENSMUSP00000095331.4, ENSMUST00000097724.10
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin

    2. NM_001310599.1 → NP_001297528.1  hyccin 2 isoform b

      See identical proteins and their annotated locations for NP_001297528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC118698, AK052638, BY265998
      Consensus CDS
      CCDS14976.1
      UniProtKB/Swiss-Prot
      Q3UMY7, Q6NV64, Q8C729
      Related
      ENSMUSP00000038718.8, ENSMUST00000038372.14
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin

    3. NM_172513.3 → NP_766101.3  hyccin 2 isoform b

      See identical proteins and their annotated locations for NP_766101.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC118698
      Consensus CDS
      CCDS14976.1
      UniProtKB/Swiss-Prot
      Q3UMY7, Q6NV64, Q8C729
      Related
      ENSMUSP00000123728.2, ENSMUST00000161600.8
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58561965..58625492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252754.2 → XP_030108614.1  hyccin 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UMY7, Q6NV64, Q8C729
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin

    2. XM_017319657.3 → XP_017175146.1  hyccin 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UMY7, Q6NV64, Q8C729
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin

    3. XM_006495832.4 → XP_006495895.1  hyccin 2 isoform X1

      See identical proteins and their annotated locations for XP_006495895.1

      UniProtKB/Swiss-Prot
      Q8C729
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin

    4. XM_017319658.3 → XP_017175147.1  hyccin 2 isoform X3

      Conserved Domains (1) summary
      pfam09790
      Location:1 → 186
      Hyccin

    5. XM_006495833.4 → XP_006495896.1  hyccin 2 isoform X1

      See identical proteins and their annotated locations for XP_006495896.1

      UniProtKB/Swiss-Prot
      Q8C729
      Conserved Domains (1) summary
      pfam09790
      Location:22 → 330
      Hyccin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C729.1 GenPept UniProtKB/Swiss-Prot:Q8C729

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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