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    Pgghg protein glucosylgalactosylhydroxylysine glucosidase [ Mus musculus (house mouse) ]

    Gene ID: 212974, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pgghgprovided by MGI
    Official Full Name
    protein glucosylgalactosylhydroxylysine glucosidaseprovided by MGI
    Primary source
    MGI:MGI:2444047
    See related
    Ensembl:ENSMUSG00000062031 AllianceGenome:MGI:2444047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Athl1; 5730511L01Rik
    Summary
    Predicted to enable protein-glucosylgalactosylhydroxylysine glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including nervous system and retina. Orthologous to human PGGHG (protein-glucosylgalactosylhydroxylysine glucosidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 26.5), adrenal adult (RPKM 24.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgghg in Genome Data Viewer
    Location:
    7 F5; 7 86.16 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140521304..140527577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140941391..140947664)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8220 Neighboring gene cDNA sequence BC023486 Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E2853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148127673-148127984 Neighboring gene interferon induced transmembrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_20461 Neighboring gene interferon induced transmembrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC28193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glucosylgalactosylhydroxylysine glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glucosylgalactosylhydroxylysine glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-glucosylgalactosylhydroxylysine glucosidase
    Names
    ATH1, acid trehalase-like 1
    acid trehalase-like protein 1
    mFLJ00228 protein
    NP_663362.2
    XP_017177593.1
    XP_017177594.1
    XP_017177595.1
    XP_030098196.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145387.5 → NP_663362.2  protein-glucosylgalactosylhydroxylysine glucosidase

      See identical proteins and their annotated locations for NP_663362.2

      Status: VALIDATED

      Source sequence(s)
      AC162287, BC056953
      Consensus CDS
      CCDS21992.1
      UniProtKB/Swiss-Prot
      Q571E9, Q8BP56, Q8R585
      Related
      ENSMUSP00000078372.5, ENSMUST00000079403.11
      Conserved Domains (2) summary
      COG1554
      Location:5 → 645
      ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
      pfam03632
      Location:291 → 605
      Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain

    RNA

    1. NR_153832.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162287
      Related
      ENSMUST00000164337.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140521304..140527577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322105.1 → XP_017177594.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X2

      Conserved Domains (1) summary
      COG1554
      Location:189 → 612
      ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

    2. XM_030242336.1 → XP_030098196.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X3

      Conserved Domains (1) summary
      COG1554
      Location:189 → 608
      ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

    3. XM_017322104.1 → XP_017177593.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1

      Related
      ENSMUST00000169736.8
      Conserved Domains (1) summary
      COG1554
      Location:5 → 649
      ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

    4. XM_017322106.1 → XP_017177595.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X4

      Conserved Domains (1) summary
      COG1554
      Location:5 → 422
      ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

    RNA

    1. XR_004934054.1 RNA Sequence

    2. XR_001785517.1 RNA Sequence

    3. XR_003946433.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP56.1 GenPept UniProtKB/Swiss-Prot:Q8BP56

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