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    N4bp3 NEDD4 binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 212706, updated on 5-Mar-2024

    Summary

    Official Symbol
    N4bp3provided by MGI
    Official Full Name
    NEDD4 binding protein 3provided by MGI
    Primary source
    MGI:MGI:2442218
    See related
    Ensembl:ENSMUSG00000001053 AllianceGenome:MGI:2442218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330016O10Rik
    Summary
    Predicted to act upstream of or within nervous system development. Located in cytoplasmic vesicle. Is expressed in several structures, including central nervous system; eye; gut; lung; and reproductive system. Orthologous to human N4BP3 (NEDD4 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 10.8), ovary adult (RPKM 7.6) and 26 other tissues See more
    Orthologs
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    Genomic context

    See N4bp3 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51533908..51541664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51643081..51651073, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene STARR-positive B cell enhancer ABC_E255 Neighboring gene NHP2 ribonucleoprotein Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene STARR-positive B cell enhancer ABC_E8400 Neighboring gene STARR-seq mESC enhancer starr_29422 Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene predicted gene, 30058 Neighboring gene STARR-seq mESC enhancer starr_29425 Neighboring gene STARR-seq mESC enhancer starr_29426 Neighboring gene STARR-positive B cell enhancer ABC_E6981 Neighboring gene STARR-seq mESC enhancer starr_29427 Neighboring gene trafficking protein particle complex 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC7136

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_positive_effect innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418169.1NP_001405098.1  NEDD4-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      AL645602
      UniProtKB/Swiss-Prot
      A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
    2. NM_145974.4NP_666086.2  NEDD4-binding protein 3

      See identical proteins and their annotated locations for NP_666086.2

      Status: VALIDATED

      Source sequence(s)
      AL645602
      Consensus CDS
      CCDS24657.1
      UniProtKB/Swiss-Prot
      A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
      Related
      ENSMUSP00000001080.10, ENSMUST00000001080.16
      Conserved Domains (2) summary
      pfam05262
      Location:256439
      Borrelia_P83; Borrelia P83/100 protein
      pfam06818
      Location:361518
      Fez1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51533908..51541664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245757.1XP_030101617.1  NEDD4-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
      Conserved Domains (2) summary
      pfam05262
      Location:256439
      Borrelia_P83; Borrelia P83/100 protein
      pfam06818
      Location:361518
      Fez1
    2. XM_006532765.5XP_006532828.1  NEDD4-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006532828.1

      UniProtKB/Swiss-Prot
      A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
      Conserved Domains (2) summary
      pfam05262
      Location:256439
      Borrelia_P83; Borrelia P83/100 protein
      pfam06818
      Location:361518
      Fez1