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    Mars2 methionine-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 212679, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mars2provided by MGI
    Official Full Name
    methionine-tRNA synthetase 2 (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:2444136
    See related
    Ensembl:ENSMUSG00000046994 AllianceGenome:MGI:2444136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MetRS; C730026E21Rik
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.2; 1 28.08 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55276336..55279217)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55237177..55240058)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene raftlin family member 2 Neighboring gene STARR-seq mESC enhancer starr_00949 Neighboring gene STARR-positive B cell enhancer ABC_E11071 Neighboring gene STARR-positive B cell enhancer ABC_E4316 Neighboring gene predicted gene 10561 Neighboring gene boule homolog, RNA binding protein Neighboring gene STARR-seq mESC enhancer starr_00956 Neighboring gene predicted gene 8292 Neighboring gene basic transcription factor 3, pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human mitochondrial methionyl-tRNA synthetase. Spencer AC, et al. Biochemistry, 2004 Aug 3. PMID 15274629
    2. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    methionine--tRNA ligase, mitochondrial
    Names
    methionine--tRNA ligase 2
    methionyl-tRNA synthetase 2
    methionyl-tRNA synthetase, mitochondrial
    mitochondrial methionine--tRNA ligase
    mitochondrial methionyl-tRNA synthetase
    mtMetRS
    NP_780648.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175439.3 → NP_780648.1  methionine--tRNA ligase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_780648.1

      Status: VALIDATED

      Source sequence(s)
      AC122223
      Consensus CDS
      CCDS14963.1
      UniProtKB/Swiss-Prot
      Q3T9W7, Q499X9, Q8BWR9, Q8BXY1
      UniProtKB/TrEMBL
      A2RT28
      Related
      ENSMUSP00000049770.9, ENSMUST00000061334.10
      Conserved Domains (3) summary
      cd07957
      Location:388 → 532
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:37 → 379
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:39 → 574
      PRK11893; methionyl-tRNA synthetase; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      55276336..55279217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499X9.2 GenPept UniProtKB/Swiss-Prot:Q499X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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