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    Iffo2 intermediate filament family orphan 2 [ Mus musculus (house mouse) ]

    Gene ID: 212632, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Iffo2provided by MGI
    Official Full Name
    intermediate filament family orphan 2provided by MGI
    Primary source
    MGI:MGI:2140675
    See related
    Ensembl:ENSMUSG00000041025 AllianceGenome:MGI:2140675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in intermediate filament. Is expressed in 4th ventricle; axial skeleton; choroid plexus; lateral ventricle choroid plexus; and rib. Orthologous to human IFFO2 (intermediate filament family orphan 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.9), ovary adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 70.73 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139257859..139347693)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139530548..139620382)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11828 Neighboring gene STARR-seq mESC enhancer starr_11829 Neighboring gene STARR-seq mESC enhancer starr_11830 Neighboring gene ER membrane protein complex subunit 1 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene nuclear encoded tRNA valine 1 (anticodon AAC) Neighboring gene VISTA enhancer mm1506 Neighboring gene STARR-seq mESC enhancer starr_11836 Neighboring gene STARR-positive B cell enhancer ABC_E6246 Neighboring gene STARR-positive B cell enhancer ABC_E4694 Neighboring gene aldehyde dehydrogenase 4 family, member A1 Neighboring gene microRNA 7020 Neighboring gene taste receptor, type 1, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36549

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intermediate filament family orphan 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205173.2 → NP_001192102.1  intermediate filament family orphan 2 isoform 1

      See identical proteins and their annotated locations for NP_001192102.1

      Status: VALIDATED

      Source sequence(s)
      AL831790, BX000454
      Consensus CDS
      CCDS57308.1
      UniProtKB/Swiss-Prot
      Q8R2V2
      Related
      ENSMUSP00000134062.2, ENSMUST00000174078.2
      Conserved Domains (2) summary
      pfam00038
      Location:189 → 478
      Filament; Intermediate filament protein
      pfam16566
      Location:212 → 259
      CREPT; Cell-cycle alteration and expression-elevated protein in tumour

    2. NM_001425010.1 → NP_001411939.1  intermediate filament family orphan 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL831790, BX000454

    3. NM_183148.4 → NP_898971.1  intermediate filament family orphan 2 isoform 2

      See identical proteins and their annotated locations for NP_898971.1

      Status: VALIDATED

      Source sequence(s)
      AL807833, AL831790, BX000454
      Consensus CDS
      CCDS18847.1
      UniProtKB/TrEMBL
      B1AZL1, J3QJZ1
      Related
      ENSMUSP00000133384.2, ENSMUST00000123827.9
      Conserved Domains (1) summary
      pfam00038
      Location:10 → 253
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139257859..139347693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253381.2 → XP_030109241.1  intermediate filament family orphan 2 isoform X2

      Conserved Domains (2) summary
      pfam15921
      Location:227 → 426
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00038
      Location:350 → 431
      Filament; Intermediate filament protein

    2. XM_030253380.2 → XP_030109240.1  intermediate filament family orphan 2 isoform X1

      Conserved Domains (1) summary
      pfam00038
      Location:189 → 478
      Filament; Intermediate filament protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2V2.2 GenPept UniProtKB/Swiss-Prot:Q8R2V2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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