Trmt1 tRNA methyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trmt1provided by MGI
Official Full Name: tRNA methyltransferase 1provided by MGI
Primary source: MGI:MGI:1289155
See related: Ensembl:ENSMUSG00000001909 AllianceGenome:MGI:1289155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6720477L24; D8Ertd812e; 6720406L13Rik
Summary: Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 20.0), testis adult (RPKM 19.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.02 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85412953..85426437)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84686324..84699808)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S694E (e-PCR)
- UniSTS:150593

D8Ertd812e (e-PCR), detects polymorphism
- UniSTS:167596

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(10)-N2)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(26)-N2)-dimethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA N2-guanine methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (guanine(26)-N(2))-dimethyltransferase

Names: TRM1 tRNA methyltransferase 1 homolog; n(2),N(2)-dimethylguanosine tRNA methyltransferase; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase

NP_001158031.1

EC 2.1.1.216

NP_001158032.1

EC 2.1.1.216

NP_001351104.1

EC 2.1.1.216

NP_001351105.1

EC 2.1.1.216

NP_932137.2

EC 2.1.1.216

XP_006530874.1

EC 2.1.1.216

XP_006530875.1

EC 2.1.1.216

XP_006530876.1

EC 2.1.1.216

XP_006530878.1

EC 2.1.1.216

XP_030099261.1

EC 2.1.1.216

XP_036009755.1

EC 2.1.1.216

XP_036009756.1

EC 2.1.1.216

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164559.1 → NP_001158031.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

See identical proteins and their annotated locations for NP_001158031.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. This variant encodes isoform 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK159467, BB055133, CN528783

Consensus CDS

CCDS40410.2

UniProtKB/Swiss-Prot

Q3TBY4, Q3TX08

UniProtKB/TrEMBL

A0A0R4IZW7

Related

ENSMUSP00000105389.3, ENSMUST00000109767.9

Conserved Domains (2) summary

smart00356
Location:599 → 625

ZnF_C3H1; zinc finger

pfam02005
Location:65 → 499

TRM; N2,N2-dimethylguanosine tRNA methyltransferase
NM_001164560.1 → NP_001158032.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses different splice sites in the first two exons which results in the use of an upstream translation start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.

Source sequence(s)

AK159467, BB055133, CN528783

Consensus CDS

CCDS52619.1

UniProtKB/TrEMBL

E9PWD4, Q3TD26

Related

ENSMUSP00000105390.3, ENSMUST00000109768.9

Conserved Domains (2) summary

smart00356
Location:592 → 618

ZnF_C3H1; zinc finger

pfam02005
Location:58 → 492

TRM; N2,N2-dimethylguanosine tRNA methyltransferase
NM_001364175.1 → NP_001351104.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform 3

Status: VALIDATED

Source sequence(s)

AK078395, AK159467, BB055133, BB579502, BB841866

Conserved Domains (2) summary

smart00356
Location:339 → 365

ZnF_C3H1; zinc finger

cl17173
Location:1 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001364176.1 → NP_001351105.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform 4

Status: VALIDATED

Source sequence(s)

AC145556

UniProtKB/TrEMBL

Q8R2M8

Conserved Domains (2) summary

smart00356
Location:574 → 600

ZnF_C3H1; zinc finger

pfam02005
Location:40 → 474

TRM; N2,N2-dimethylguanosine tRNA methyltransferase
NM_198020.2 → NP_932137.2 tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

See identical proteins and their annotated locations for NP_932137.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.

Source sequence(s)

AK159467, BB055133, CN528783

Consensus CDS

CCDS40410.2

UniProtKB/Swiss-Prot

Q3TBY4, Q3TX08

UniProtKB/TrEMBL

A0A0R4IZW7

Related

ENSMUSP00000001974.5, ENSMUST00000001974.11

Conserved Domains (2) summary

smart00356
Location:599 → 625

ZnF_C3H1; zinc finger

pfam02005
Location:65 → 499

TRM; N2,N2-dimethylguanosine tRNA methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85412953..85426437

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243401.2 → XP_030099261.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

Conserved Domains (2) summary

smart00356
Location:339 → 365

ZnF_C3H1; zinc finger

cl17173
Location:1 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006530811.2 → XP_006530874.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

UniProtKB/TrEMBL

Q8R2M8

Conserved Domains (2) summary

smart00356
Location:574 → 600

ZnF_C3H1; zinc finger

pfam02005
Location:40 → 474

TRM; N2,N2-dimethylguanosine tRNA methyltransferase
XM_006530812.5 → XP_006530875.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

See identical proteins and their annotated locations for XP_006530875.1

Conserved Domains (2) summary

smart00356
Location:408 → 434

ZnF_C3H1; zinc finger

cl17173
Location:1 → 308

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036153862.1 → XP_036009755.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

Conserved Domains (2) summary

smart00356
Location:339 → 365

ZnF_C3H1; zinc finger

cl17173
Location:1 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006530813.2 → XP_006530876.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

See identical proteins and their annotated locations for XP_006530876.1

Conserved Domains (2) summary

smart00356
Location:408 → 434

ZnF_C3H1; zinc finger

cl17173
Location:1 → 308

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036153863.1 → XP_036009756.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

Conserved Domains (2) summary

smart00356
Location:339 → 365

ZnF_C3H1; zinc finger

cl17173
Location:1 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006530815.2 → XP_006530878.1 tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

Conserved Domains (2) summary

smart00356
Location:339 → 365

ZnF_C3H1; zinc finger

cl17173
Location:1 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...