Mtg1 mitochondrial ribosome-associated GTPase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtg1provided by MGI
Official Full Name: mitochondrial ribosome-associated GTPase 1provided by MGI
Primary source: MGI:MGI:2685015
See related: Ensembl:ENSMUSG00000039018 AllianceGenome:MGI:2685015
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm169; Gtpbp7
Summary: Predicted to enable GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Predicted to act upstream of or within regulation of translation. Located in mitochondrion. Orthologous to human MTG1 (mitochondrial ribosome associated GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 10.0), kidney adult (RPKM 8.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 85.16 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (139717477..139730699)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (140137564..140150786)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dampening oxidative stress with N-acetylcysteine (NAC) lowered hypertrophy in MTG1 KO to WT levels. Collectively, our data indicate that MTG1 protects against pressure overload-induced cardiac hypertrophy and dysfunction by preserving mitochondrial function and reducing oxidative stress and downstream TAK1 stress signaling.
Title: Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial ribosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial ribosome-associated GTPase 1

Names: GTP binding protein 7 (putative); GTP-binding protein 7; mitochondrial GTPase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199301.2 → NP_955005.2 mitochondrial ribosome-associated GTPase 1

See identical proteins and their annotated locations for NP_955005.2

Status: VALIDATED

Source sequence(s)

AK140018, AK144453, AK144625, BY240360

Consensus CDS

CCDS52432.1

UniProtKB/Swiss-Prot

Q3UMX2, Q3UN50, Q8R2R6

Related

ENSMUSP00000036491.9, ENSMUST00000036977.9

Conserved Domains (2) summary

cd01856
Location:29 → 206

YlqF; Circularly permuted YlqF GTPase

TIGR03596
Location:29 → 319

GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

139717477..139730699

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242335.2 → XP_030098195.1 mitochondrial ribosome-associated GTPase 1 isoform X2

Conserved Domains (1) summary

cd01856
Location:1 → 166

YlqF; Circularly permuted YlqF GTPase
XM_036152879.1 → XP_036008772.1 mitochondrial ribosome-associated GTPase 1 isoform X1

Conserved Domains (1) summary

cd01856
Location:22 → 191

YlqF; Circularly permuted YlqF GTPase
XM_006536170.1 → XP_006536233.1 mitochondrial ribosome-associated GTPase 1 isoform X2

Conserved Domains (1) summary

cd01856
Location:1 → 166

YlqF; Circularly permuted YlqF GTPase