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    Dcaf15 DDB1 and CUL4 associated factor 15 [ Mus musculus (house mouse) ]

    Gene ID: 212123, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dcaf15provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 15provided by MGI
    Primary source
    MGI:MGI:2684420
    See related
    Ensembl:ENSMUSG00000037103 AllianceGenome:MGI:2684420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720484B16
    Summary
    Predicted to enable small molecule binding activity. Predicted to be involved in protein polyubiquitination and regulation of natural killer cell activation. Predicted to act upstream of or within immune system process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF15 (DDB1 and CUL4 associated factor 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 77.9), thymus adult (RPKM 65.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C2; 8 40.3 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84823698..84831426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84097069..84104797, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E73 Neighboring gene STARR-positive B cell enhancer ABC_E5024 Neighboring gene predicted gene 10643 Neighboring gene regulatory factor X, 1 (influences HLA class II expression) Neighboring gene microRNA 709 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86628640-86628941 Neighboring gene predicted gene, 39210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86650788-86650941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86651237-86651346 Neighboring gene podocan-like 1 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene break repair meiotic recombinase recruitment factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. Zhang YL, et al. EMBO J, 2018 Sep 14. PMID 30111536, Free PMC Article
    2. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66593

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357322.1 → NP_001344251.1  DDB1- and CUL4-associated factor 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159266, AK032982, BB803815, BY273847
      Consensus CDS
      CCDS90424.1
      UniProtKB/Swiss-Prot
      Q3U305, Q6PFH3, Q8BMB2
      Related
      ENSMUSP00000147690.2, ENSMUST00000210279.2
      Conserved Domains (1) summary
      pfam14939
      Location:51 → 259
      DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

    2. NM_172502.4 → NP_766090.2  DDB1- and CUL4-associated factor 15 isoform 1

      See identical proteins and their annotated locations for NP_766090.2

      Status: VALIDATED

      Source sequence(s)
      AC159266
      Consensus CDS
      CCDS40406.1
      UniProtKB/Swiss-Prot
      Q6PFH3
      Related
      ENSMUSP00000038568.8, ENSMUST00000041367.9
      Conserved Domains (1) summary
      pfam14939
      Location:51 → 259
      DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84823698..84831426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243400.1 → XP_030099260.1  DDB1- and CUL4-associated factor 15 isoform X1

      Conserved Domains (1) summary
      pfam14939
      Location:51 → 259
      DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

    2. XM_011248336.1 → XP_011246638.1  DDB1- and CUL4-associated factor 15 isoform X2

      Conserved Domains (2) summary
      cd20913
      Location:223 → 473
      DCAF15-CTD; C-terminal domain of DDB1- and CUL4-associated factor 15
      cl20823
      Location:9 → 95
      DCAF15-NTD; N-terminal domain of DDB1- and CUL4-associated factor 15

    3. XM_036153861.1 → XP_036009754.1  DDB1- and CUL4-associated factor 15 isoform X2

      Conserved Domains (2) summary
      cd20913
      Location:223 → 473
      DCAF15-CTD; C-terminal domain of DDB1- and CUL4-associated factor 15
      cl20823
      Location:9 → 95
      DCAF15-NTD; N-terminal domain of DDB1- and CUL4-associated factor 15
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFH3.1 GenPept UniProtKB/Swiss-Prot:Q6PFH3

    Gene LinkOut

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