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    Ap1ar adaptor-related protein complex 1 associated regulatory protein [ Mus musculus (house mouse) ]

    Gene ID: 211556, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ap1arprovided by MGI
    Official Full Name
    adaptor-related protein complex 1 associated regulatory proteinprovided by MGI
    Primary source
    MGI:MGI:2384822
    See related
    Ensembl:ENSMUSG00000074238 AllianceGenome:MGI:2384822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gadkin
    Summary
    Predicted to enable AP-1 adaptor complex binding activity; Arp2/3 complex binding activity; and kinesin binding activity. Acts upstream of or within several processes, including negative regulation of cell motility; negative regulation of substrate adhesion-dependent cell spreading; and regulation of Arp2/3 complex-mediated actin nucleation. Located in endosome. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Orthologous to human AP1AR (adaptor related protein complex 1 associated regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 18.9), colon adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 G2; 3 56.54 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127600656..127631148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127807007..127837523, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alpha-kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene TRAF-interacting protein with forkhead-associated domain Neighboring gene STARR-positive B cell enhancer ABC_E6122 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127540571-127540758 Neighboring gene predicted gene 43653 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127571005-127571206 Neighboring gene predicted gene, 35585 Neighboring gene family with sequence similarity 241, member A Neighboring gene STARR-positive B cell enhancer ABC_E11217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Gadkin Affects Dendritic Cell Migration In Vitro. Schachtner H, et al. PLoS One, 2015. PMID 26624014, Free PMC Article
    2. Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking. Hirst J, et al. Mol Biol Cell, 2015 Sep 1. PMID 26179914, Free PMC Article
    3. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Mertins P, et al. Cell Rep, 2017 Jun 27. PMID 28658630, Free PMC Article
    4. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Maritzen T, et al. Proc Natl Acad Sci U S A, 2012 Jun 26. PMID 22689987, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7434

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AP-1 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Arp2/3 complex-mediated actin nucleation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Arp2/3 complex-mediated actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle targeting, trans-Golgi to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle targeting, trans-Golgi to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex-associated regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346718.3 → NP_001333647.1  AP-1 complex-associated regulatory protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163391
      Consensus CDS
      CCDS84673.1
      UniProtKB/TrEMBL
      A0A0G2JG85
      Related
      ENSMUSP00000143466.2, ENSMUST00000200409.5

    2. NM_001411484.1 → NP_001398413.1  AP-1 complex-associated regulatory protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163391

    3. NM_001411486.1 → NP_001398415.1  AP-1 complex-associated regulatory protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163391

    4. NM_001411487.1 → NP_001398416.1  AP-1 complex-associated regulatory protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163391

    5. NM_001411488.1 → NP_001398417.1  AP-1 complex-associated regulatory protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC163391

    6. NM_001411489.1 → NP_001398418.1  AP-1 complex-associated regulatory protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC163391

    7. NM_001411490.1 → NP_001398419.1  AP-1 complex-associated regulatory protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC163391

    8. NM_145964.4 → NP_666076.2  AP-1 complex-associated regulatory protein isoform 1

      See identical proteins and their annotated locations for NP_666076.2

      Status: VALIDATED

      Source sequence(s)
      AC163391
      Consensus CDS
      CCDS38629.1
      UniProtKB/TrEMBL
      E9PYF7
      Related
      ENSMUSP00000059669.7, ENSMUST00000051737.8
      Conserved Domains (1) summary
      pfam15745
      Location:24 → 298
      AP1AR; AP-1 complex-associated regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127600656..127631148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501241.4 → XP_006501304.1  AP-1 complex-associated regulatory protein isoform X2

      Conserved Domains (1) summary
      pfam15745
      Location:74 → 345
      AP1AR; AP-1 complex-associated regulatory protein

    2. XM_006501242.3 → XP_006501305.1  AP-1 complex-associated regulatory protein isoform X3

      Conserved Domains (1) summary
      pfam15745
      Location:99 → 337
      AP1AR; AP-1 complex-associated regulatory protein

    3. XM_006501240.3 → XP_006501303.1  AP-1 complex-associated regulatory protein isoform X1

      Conserved Domains (1) summary
      pfam15745
      Location:99 → 370
      AP1AR; AP-1 complex-associated regulatory protein

    4. XM_006501245.3 → XP_006501308.1  AP-1 complex-associated regulatory protein isoform X6

      Conserved Domains (1) summary
      pfam15745
      Location:18 → 289
      AP1AR; AP-1 complex-associated regulatory protein

    5. XM_006501243.3 → XP_006501306.1  AP-1 complex-associated regulatory protein isoform X4

      Conserved Domains (1) summary
      pfam15745
      Location:53 → 324
      AP1AR; AP-1 complex-associated regulatory protein
    Nucleotide Protein Strain
    Heading Accession and Version

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