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    Tsga10 testis specific 10 [ Mus musculus (house mouse) ]

    Gene ID: 211484, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tsga10provided by MGI
    Official Full Name
    testis specific 10provided by MGI
    Primary source
    MGI:MGI:2685063
    See related
    Ensembl:ENSMUSG00000060771 AllianceGenome:MGI:2685063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm217; Mtsga10; 4933432N21Rik
    Summary
    Predicted to enable structural molecule activity. Acts upstream of or within cell projection assembly. Located in cytoplasm; neuron projection; and sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 26. Orthologous to human TSGA10 (testis specific 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 5.9), CNS E18 (RPKM 1.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tsga10 in Genome Data Viewer
    Location:
    1 B; 1 15.88 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37793651..37905507, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37754570..37866426, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene RIKEN cDNA 4930470B04 gene Neighboring gene STARR-seq mESC enhancer starr_00681 Neighboring gene STARR-seq mESC enhancer starr_00682 Neighboring gene predicted gene, 39628 Neighboring gene STARR-seq mESC enhancer starr_00684 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37921599-37921900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37922129-37922238 Neighboring gene lipoyltransferase 1 Neighboring gene MIT, microtubule interacting and transport, domain containing 1 Neighboring gene mitochondrial ribosomal protein L30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice. Luo G, et al. Andrology, 2021 Jan. PMID 32790169
    2. Tsga10 expression correlates with sperm profiles in the adult formalin-exposed mice. Tajaddini Mahani S, et al. Andrologia, 2016 Dec. PMID 26791599
    3. Expression of Tsga10 sperm tail protein in embryogenesis and neural development: from cilium to cell division. Behnam B, et al. Biochem Biophys Res Commun, 2006 Jun 16. PMID 16643851
    4. Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein. Modarressi MH, et al. Biol Reprod, 2004 Mar. PMID 14585816, Free PMC Article
    5. TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. Hägele S, et al. FEBS Lett, 2006 Jun 26. PMID 16777103

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice.
      Title: Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice.
    2. This study also shows that Tsga10 expression protects sperm dysfunction in formalin plus manganese-exposed mice resulting in better preservation of spermatozoa and improvement of male fertility.
      Title: Tsga10 expression correlates with sperm profiles in the adult formalin-exposed mice.
    3. Tsga10 expression starts in 4.5-7.5 dpc mouse embryos and continues throughout embryogenesis.
      Title: Expression of Tsga10 sperm tail protein in embryogenesis and neural development: from cilium to cell division.
    4. HIF-1alpha nuclear localization and HIF-1 transcriptional activity were significantly affected by overexpressed TSGA10
      Title: TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.
    5. Tsga10 plays a role in the sperm tail fibrous sheath.
      Title: Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testis-specific gene 10 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290720.1 → NP_001277649.1  testis-specific gene 10 protein isoform 2

      See identical proteins and their annotated locations for NP_001277649.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' structure and 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC123068, AK030254, AK164954, BX637247
      Consensus CDS
      CCDS69883.1
      UniProtKB/Swiss-Prot
      Q6NY15
      Related
      ENSMUSP00000085391.4, ENSMUST00000088072.10
      Conserved Domains (2) summary
      COG1196
      Location:24 → 580
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:223 → 486
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_001290721.1 → NP_001277650.1  testis-specific gene 10 protein isoform 3

      See identical proteins and their annotated locations for NP_001277650.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate 3' structure and 3' terminal exon, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC123068, AK030254, BC053407, BX637247, CJ046680, CK789086
      Consensus CDS
      CCDS78571.1
      UniProtKB/Swiss-Prot
      Q6NY15
      Related
      ENSMUSP00000110552.2, ENSMUST00000114902.8
      Conserved Domains (2) summary
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:223 → 498
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. NM_207228.3 → NP_997111.1  testis-specific gene 10 protein isoform 1

      See identical proteins and their annotated locations for NP_997111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC119189, AC123068, AK030254, BC053407, CJ046680, CK789086
      Consensus CDS
      CCDS14894.1
      UniProtKB/Swiss-Prot
      Q68RJ4, Q6NY15, Q8K3V2
      Related
      ENSMUSP00000048859.9, ENSMUST00000041815.15
      Conserved Domains (1) summary
      cl25732
      Location:223 → 498
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. NR_110976.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate 3' structure and terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123068, AK030254, BC053407, CJ046680
      Related
      ENSMUST00000151735.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      37793651..37905507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495822.4 → XP_006495885.1  testis-specific gene 10 protein isoform X2

      UniProtKB/TrEMBL
      A0A668KLF4
      Conserved Domains (2) summary
      COG1196
      Location:224 → 834
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:423 → 698
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_030252660.2 → XP_030108520.1  testis-specific gene 10 protein isoform X4

      UniProtKB/TrEMBL
      A0A668KLF4
      Conserved Domains (2) summary
      COG1196
      Location:48 → 691
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:423 → 686
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. XM_017319575.2 → XP_017175064.1  testis-specific gene 10 protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_017319576.2 → XP_017175065.1  testis-specific gene 10 protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_017319574.2 → XP_017175063.1  testis-specific gene 10 protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_030252667.1 → XP_030108527.1  testis-specific gene 10 protein isoform X8

      Conserved Domains (2) summary
      TIGR02169
      Location:142 → 417
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam15921
      Location:36 → 599
      CCDC158; Coiled-coil domain-containing protein 158

    7. XM_036163236.1 → XP_036019129.1  testis-specific gene 10 protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_011238461.3 → XP_011236763.1  testis-specific gene 10 protein isoform X1

      UniProtKB/TrEMBL
      A0A668KLF4
      Related
      ENSMUSP00000159265.2, ENSMUST00000239367.2
      Conserved Domains (2) summary
      COG1196
      Location:224 → 834
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:423 → 698
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    9. XM_017319571.3 → XP_017175060.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A668KLF4
      Conserved Domains (3) summary
      TIGR01843
      Location:655 → 785
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      COG1196
      Location:48 → 691
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:423 → 686
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    10. XM_006495823.5 → XP_006495886.1  testis-specific gene 10 protein isoform X5

      UniProtKB/TrEMBL
      A0A668KLF4
      Conserved Domains (2) summary
      COG1196
      Location:48 → 691
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:423 → 686
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    11. XM_030252666.1 → XP_030108526.1  testis-specific gene 10 protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_036163239.1 → XP_036019132.1  testis-specific gene 10 protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:361 → 652
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_017319578.3 → XP_017175067.1  testis-specific gene 10 protein isoform X8

      Conserved Domains (2) summary
      TIGR02169
      Location:142 → 417
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam15921
      Location:36 → 599
      CCDC158; Coiled-coil domain-containing protein 158

    14. XM_030252668.1 → XP_030108528.1  testis-specific gene 10 protein isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:30 → 396
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:223 → 469
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    15. XM_011238463.4 → XP_011236765.1  testis-specific gene 10 protein isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:48 → 667
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:423 → 669
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    16. XM_036163247.1 → XP_036019140.1  testis-specific gene 10 protein isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:41 → 386
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:274 → 517
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    17. XM_017319581.3 → XP_017175070.1  testis-specific gene 10 protein isoform X11

      Conserved Domains (2) summary
      TIGR02168
      Location:142 → 471
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl27037
      Location:50 → 96
      FlaC_arch; Flagella accessory protein C (FlaC)

    RNA

    1. XR_865225.3 RNA Sequence

    2. XR_003954349.2 RNA Sequence

    3. XR_001783692.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NY15.1 GenPept UniProtKB/Swiss-Prot:Q6NY15

    Gene LinkOut

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