Suox sulfite oxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Suoxprovided by MGI
Official Full Name: sulfite oxidaseprovided by MGI
Primary source: MGI:MGI:2446117
See related: Ensembl:ENSMUSG00000049858 AllianceGenome:MGI:2446117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SO
Summary: Predicted to enable heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Predicted to be involved in response to nutrient and sulfur compound metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 75.1), genital fat pad adult (RPKM 64.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.12 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128505756..128509787, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128669887..128673918, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased hippocampal excitability in miR-324-null mice.
Title: Increased hippocampal excitability in miR-324-null mice.
Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase.
Title: Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase.
This finding suggests the possibility to use oxygen-reactive SO variants in sulfite detoxification, as the loss of SO activity is causing severe neurodegeneration
Title: Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency.
the identified molecular hierarchy of SO maturation represents a novel link between the canonical presequence pathway and folding-trap mechanisms of mitochondrial import
Title: Cofactor-dependent maturation of mammalian sulfite oxidase links two mitochondrial import pathways.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Suox (e-PCR), detects polymorphism
- UniSTS:507254

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molybdenum ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables sulfite oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfite oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in sulfur compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sulfite oxidase, mitochondrial

NP_776094.2

EC 1.8.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173733.3 → NP_776094.2 sulfite oxidase, mitochondrial precursor

See identical proteins and their annotated locations for NP_776094.2

Status: VALIDATED

Source sequence(s)

AC117232

Consensus CDS

CCDS24285.1

UniProtKB/Swiss-Prot

Q3U3S5, Q3UEP6, Q8R086

Related

ENSMUSP00000056195.8, ENSMUST00000054764.9

Conserved Domains (3) summary

PLN00177
Location:169 → 544

PLN00177; sulfite oxidase; Provisional

cd02111
Location:186 → 544

eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...

pfam00173
Location:85 → 161

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain