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    Brcc3 BRCA1/BRCA2-containing complex, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 210766, updated on 7-Apr-2024

    Summary

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    Official Symbol
    Brcc3provided by MGI
    Official Full Name
    BRCA1/BRCA2-containing complex, subunit 3provided by MGI
    Primary source
    MGI:MGI:2389572
    See related
    Ensembl:ENSMUSG00000031201 AllianceGenome:MGI:2389572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6.1A
    Summary
    Predicted to enable enzyme regulator activity; peptidase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within response to X-ray. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 5.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A7.3; X 38.22 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (74460234..74499307)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (75416628..75455702)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene STARR-seq mESC enhancer starr_47382 Neighboring gene FUN14 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11683 Neighboring gene C-X9-C motif containing 4 Neighboring gene mature T cell proliferation 1 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene Neighboring gene non-histone chromosomal protein HMG-14 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3. Kim JS, et al. Cell Mol Immunol, 2023 Feb. PMID 36600050, Free PMC Article
    2. Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36. Singh M, et al. Inflamm Res, 2019 Dec. PMID 31485755
    3. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Py BF, et al. Mol Cell, 2013 Jan 24. PMID 23246432
    4. Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. Zhou L, et al. J Allergy Clin Immunol, 2021 Jan. PMID 32941940
    5. The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another. Fisch P, et al. Oncogene, 1993 Dec. PMID 8247530

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.
      Title: BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.
    2. BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis.
      Title: BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis.
    3. Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
      Title: Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
    4. Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
      Title: Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
    5. The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
      Title: The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
    6. We report here for the first time that oxLDL-induced NLRP3 inflammasome stabilization and activation occurs due to modulation by BRCC36 activity in murine macrophages.
      Title: Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36.
    7. The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 activity by promoting its deubiquitination.
      Title: Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2/M transition checkpoint NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA damage checkpoint NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to X-ray ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BRCA1-A complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRISC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lys-63-specific deubiquitinase BRCC36
    Names
    6.1A protein
    BRCA1-A complex subunit BRCC36
    BRCA1/BRCA2-containing complex subunit 36
    BRISC complex subunit BRCC36
    NP_001159929.1
    NP_001159931.1
    NP_001345665.1
    NP_001345666.1
    NP_666068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166457.1 → NP_001159929.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_001159929.1

      Status: VALIDATED

      Source sequence(s)
      AK149844, AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025
      Related
      ENSMUSP00000033544.8, ENSMUST00000033544.14
      Conserved Domains (1) summary
      cd08068
      Location:13 → 267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    2. NM_001166459.1 → NP_001159931.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_001159931.1

      Status: VALIDATED

      Source sequence(s)
      AK011876, AL671860, CD774860
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025
      Conserved Domains (1) summary
      cd08068
      Location:13 → 267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    3. NM_001358736.1 → NP_001345665.1  lys-63-specific deubiquitinase BRCC36

      Status: VALIDATED

      Source sequence(s)
      AL671860, CD774860
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025
      Conserved Domains (1) summary
      cd08068
      Location:13 → 267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    4. NM_001358737.1 → NP_001345666.1  lys-63-specific deubiquitinase BRCC36

      Status: VALIDATED

      Source sequence(s)
      AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025
      Related
      ENSMUSP00000109708.2, ENSMUST00000114074.8
      Conserved Domains (1) summary
      cd08068
      Location:13 → 267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    5. NM_145956.4 → NP_666068.1  lys-63-specific deubiquitinase BRCC36

      See identical proteins and their annotated locations for NP_666068.1

      Status: VALIDATED

      Source sequence(s)
      AK030736, AL671860, BC048179
      Consensus CDS
      CCDS41031.1
      UniProtKB/Swiss-Prot
      A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025
      Conserved Domains (1) summary
      cd08068
      Location:13 → 267
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      74460234..74499307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46737.1 GenPept UniProtKB/Swiss-Prot:P46737

    Gene LinkOut

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